Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1232043..1232674 Replicon chromosome
Accession NZ_CP112996
Organism Mycobacterium tuberculosis variant bovis strain 2018/0565

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U4F9D0
Locus tag ORO19_RS05895 Protein ID WP_003405820.1
Coordinates 1232043..1232354 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TGZ7
Locus tag ORO19_RS05900 Protein ID WP_003405836.1
Coordinates 1232354..1232674 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORO19_RS05875 (ORO19_05875) 1227525..1228949 - 1425 WP_003405805.1 class II fumarate hydratase -
ORO19_RS05880 (ORO19_05880) 1228980..1230068 - 1089 WP_003898726.1 class II fructose-bisphosphatase -
ORO19_RS05885 (ORO19_05885) 1230124..1230768 + 645 WP_003915494.1 DUF4245 domain-containing protein -
ORO19_RS05890 (ORO19_05890) 1230775..1231931 - 1157 Protein_1160 AI-2E family transporter -
ORO19_RS05895 (ORO19_05895) 1232043..1232354 - 312 WP_003405820.1 type II toxin-antitoxin system toxin endoribonuclease MazF3 Toxin
ORO19_RS05900 (ORO19_05900) 1232354..1232674 - 321 WP_003405836.1 type II toxin-antitoxin system antitoxin MazE3 Antitoxin
ORO19_RS05905 (ORO19_05905) 1232684..1234220 + 1537 Protein_1163 carboxylesterase/lipase family protein -
ORO19_RS05910 (ORO19_05910) 1234227..1235339 - 1113 WP_003405840.1 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase -
ORO19_RS05915 (ORO19_05915) 1235349..1235606 - 258 WP_003405844.1 exodeoxyribonuclease VII small subunit -
ORO19_RS05920 (ORO19_05920) 1235596..1236843 - 1248 WP_003405846.1 exodeoxyribonuclease VII large subunit -
ORO19_RS05925 (ORO19_05925) 1236840..1237478 - 639 WP_003898730.1 lipid droplet-associated protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11061.82 Da        Isoelectric Point: 4.9371

>T265001 WP_003405820.1 NZ_CP112996:c1232354-1232043 [Mycobacterium tuberculosis variant bovis]
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNIQTIPVCDLGRQIGYL
LASQEPALAEAIGNAFDLDWVVA

Download         Length: 312 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11394.83 Da        Isoelectric Point: 5.1236

>AT265001 WP_003405836.1 NZ_CP112996:c1232674-1232354 [Mycobacterium tuberculosis variant bovis]
MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEI
LATNTSATGDLDTLAGHCARTALDID

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F9D0

Antitoxin

Source ID Structure
AlphaFold DB G0TGZ7

References