Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1015207..1015826 Replicon chromosome
Accession NZ_CP112996
Organism Mycobacterium tuberculosis variant bovis strain 2018/0565

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag ORO19_RS04825 Protein ID WP_003404726.1
Coordinates 1015392..1015826 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID G0TFQ5
Locus tag ORO19_RS04820 Protein ID WP_003404724.1
Coordinates 1015207..1015386 (+) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORO19_RS04805 (ORO19_04805) 1010680..1012260 + 1581 WP_011799139.1 serine hydrolase -
ORO19_RS04810 (ORO19_04810) 1012257..1014650 + 2394 WP_003898639.1 cation-translocating P-type ATPase -
ORO19_RS04815 (ORO19_04815) 1014923..1015081 + 159 WP_003404720.1 hypothetical protein -
ORO19_RS04820 (ORO19_04820) 1015207..1015386 + 180 WP_003404724.1 antitoxin Antitoxin
ORO19_RS04825 (ORO19_04825) 1015392..1015826 + 435 WP_003404726.1 SRPBCC family protein Toxin
ORO19_RS04830 (ORO19_04830) 1015924..1016697 + 774 WP_003404735.1 VOC family protein -
ORO19_RS04835 (ORO19_04835) 1016762..1017211 + 450 WP_003404738.1 hypothetical protein -
ORO19_RS04840 (ORO19_04840) 1017346..1017576 - 231 WP_003898642.1 hypothetical protein -
ORO19_RS04845 (ORO19_04845) 1017743..1019251 - 1509 WP_010950467.1 carotenoid oxygenase family protein -
ORO19_RS04850 (ORO19_04850) 1019253..1020491 - 1239 WP_003404744.1 acetyl-CoA acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15754.47 Da        Isoelectric Point: 9.7977

>T264998 WP_003404726.1 NZ_CP112996:1015392-1015826 [Mycobacterium tuberculosis variant bovis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Download         Length: 435 bp

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6394.06 Da        Isoelectric Point: 4.3059

>AT264998 WP_003404724.1 NZ_CP112996:1015207-1015386 [Mycobacterium tuberculosis variant bovis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLQDAASNVVGMSDQQS

Download         Length: 180 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB G0TFQ5

References