Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 843039..843748 Replicon chromosome
Accession NZ_CP112996
Organism Mycobacterium tuberculosis variant bovis strain 2018/0565

Toxin (Protein)


Gene name vapC Uniprot ID P9WF74
Locus tag ORO19_RS03985 Protein ID WP_003403837.1
Coordinates 843320..843748 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TEX4
Locus tag ORO19_RS03980 Protein ID WP_003403834.1
Coordinates 843039..843296 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORO19_RS03975 (ORO19_03975) 840219..842948 + 2730 WP_010950437.1 PE family protein -
ORO19_RS03980 (ORO19_03980) 843039..843296 + 258 WP_003403834.1 ribbon-helix-helix protein, CopG family Antitoxin
ORO19_RS03985 (ORO19_03985) 843320..843748 + 429 WP_003403837.1 type II toxin-antitoxin system VapC family toxin Toxin
ORO19_RS03990 (ORO19_03990) 843829..843966 - 138 WP_003403839.1 hypothetical protein -
ORO19_RS03995 (ORO19_03995) 844125..844370 + 246 WP_003403841.1 hypothetical protein -
ORO19_RS04000 (ORO19_04000) 844439..845323 - 885 WP_003403844.1 3-hydroxyisobutyrate dehydrogenase -
ORO19_RS04005 (ORO19_04005) 845334..846506 - 1173 WP_010950438.1 acyl-CoA dehydrogenase family protein -
ORO19_RS04010 (ORO19_04010) 846513..848045 - 1533 WP_010950439.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-36)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15831.27 Da        Isoelectric Point: 7.5536

>T264997 WP_003403837.1 NZ_CP112996:843320-843748 [Mycobacterium tuberculosis variant bovis]
MFLLDANVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLATNRRIFEIPSPRAEAFAFVEAVTAQPHHL
PTNPGPRHLMLLRKLCDEADASGDLIPDAVLAAIAVGHHCAVVSLDRDFARFASVRHIRPPL

Download         Length: 429 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9114.28 Da        Isoelectric Point: 10.6530

>AT264997 WP_003403834.1 NZ_CP112996:843039-843296 [Mycobacterium tuberculosis variant bovis]
MRTTVSISDEILAAAKRRARERGQSLGAVIEDALRREFAAAHVGGARPTVPVFDGGTGPRRGIDLTSNRALSEVLDEGLE
LNSRK

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CDR3

Antitoxin

Source ID Structure
AlphaFold DB G0TEX4

References