Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 717559..718208 Replicon chromosome
Accession NZ_CP112996
Organism Mycobacterium tuberculosis variant bovis strain 2018/0565

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag ORO19_RS03295 Protein ID WP_003403236.1
Coordinates 717813..718208 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag ORO19_RS03290 Protein ID WP_003403235.1
Coordinates 717559..717813 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORO19_RS03265 (ORO19_03265) 712684..712767 + 84 Protein_647 galactose-1-phosphate uridylyltransferase -
ORO19_RS03270 (ORO19_03270) 712786..713868 + 1083 WP_031702118.1 galactose-1-phosphate uridylyltransferase -
ORO19_RS03275 (ORO19_03275) 713865..714956 + 1092 WP_003403225.1 galactokinase -
ORO19_RS03280 (ORO19_03280) 715351..716508 + 1158 WP_003903091.1 hypothetical protein -
ORO19_RS03285 (ORO19_03285) 716519..717466 + 948 WP_003403232.1 DUF732 domain-containing protein -
ORO19_RS03290 (ORO19_03290) 717559..717813 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
ORO19_RS03295 (ORO19_03295) 717813..718208 + 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
ORO19_RS03300 (ORO19_03300) 718302..719042 - 741 WP_003403239.1 TVP38/TMEM64 family protein -
ORO19_RS03305 (ORO19_03305) 719174..719434 + 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
ORO19_RS03310 (ORO19_03310) 719431..719838 + 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
ORO19_RS03315 (ORO19_03315) 719910..721061 - 1152 WP_003403248.1 FIST N-terminal domain-containing protein -
ORO19_RS03320 (ORO19_03320) 721154..722881 - 1728 WP_010950423.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T264991 WP_003403236.1 NZ_CP112996:717813-718208 [Mycobacterium tuberculosis variant bovis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT264991 WP_003403235.1 NZ_CP112996:717559-717813 [Mycobacterium tuberculosis variant bovis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
PDB 4XGR
PDB 4XGQ
AlphaFold DB A0A7U4BSC2

References