Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 711930..712555 Replicon chromosome
Accession NZ_CP112996
Organism Mycobacterium tuberculosis variant bovis strain 2018/0565

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag ORO19_RS03260 Protein ID WP_003403218.1
Coordinates 712154..712555 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag ORO19_RS03255 Protein ID WP_003403213.1
Coordinates 711930..712157 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORO19_RS03230 (ORO19_03230) 707109..707330 - 222 WP_003898525.1 DUF4926 domain-containing protein -
ORO19_RS03235 (ORO19_03235) 707472..708077 + 606 WP_003898526.1 hypothetical protein -
ORO19_RS03240 (ORO19_03240) 708096..710663 - 2568 WP_003900188.1 SEC-C metal-binding domain-containing protein -
ORO19_RS03245 (ORO19_03245) 710747..711496 + 750 WP_003898528.1 hypothetical protein -
ORO19_RS03250 (ORO19_03250) 711493..711735 + 243 WP_003403210.1 hypothetical protein -
ORO19_RS03255 (ORO19_03255) 711930..712157 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
ORO19_RS03260 (ORO19_03260) 712154..712555 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
ORO19_RS03265 (ORO19_03265) 712684..712767 + 84 Protein_647 galactose-1-phosphate uridylyltransferase -
ORO19_RS03270 (ORO19_03270) 712786..713868 + 1083 WP_031702118.1 galactose-1-phosphate uridylyltransferase -
ORO19_RS03275 (ORO19_03275) 713865..714956 + 1092 WP_003403225.1 galactokinase -
ORO19_RS03280 (ORO19_03280) 715351..716508 + 1158 WP_003903091.1 hypothetical protein -
ORO19_RS03285 (ORO19_03285) 716519..717466 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T264990 WP_003403218.1 NZ_CP112996:712154-712555 [Mycobacterium tuberculosis variant bovis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT264990 WP_003403213.1 NZ_CP112996:711930-712157 [Mycobacterium tuberculosis variant bovis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References