Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 364894..365537 Replicon chromosome
Accession NZ_CP112996
Organism Mycobacterium tuberculosis variant bovis strain 2018/0565

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag ORO19_RS01600 Protein ID WP_003401566.1
Coordinates 365112..365537 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag ORO19_RS01595 Protein ID WP_003401563.1
Coordinates 364894..365115 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORO19_RS01570 (ORO19_01570) 359968..360771 - 804 WP_003401540.1 Stf0 family sulphotransferase -
ORO19_RS01575 (ORO19_01575) 360781..362178 - 1398 WP_003401544.1 sulfatase -
ORO19_RS01580 (ORO19_01580) 362357..364177 + 1821 WP_268102241.1 PE family protein -
ORO19_RS01585 (ORO19_01585) 364320..364547 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
ORO19_RS01590 (ORO19_01590) 364544..364846 + 303 WP_003401560.1 toxin-antitoxin system toxin -
ORO19_RS01595 (ORO19_01595) 364894..365115 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
ORO19_RS01600 (ORO19_01600) 365112..365537 + 426 WP_003401566.1 PIN domain nuclease Toxin
ORO19_RS01605 (ORO19_01605) 365673..366305 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
ORO19_RS01610 (ORO19_01610) 366302..367210 + 909 WP_003900117.1 protochlorophyllide reductase -
ORO19_RS01615 (ORO19_01615) 367218..367808 - 591 WP_234712434.1 hypothetical protein -
ORO19_RS01620 (ORO19_01620) 367801..367851 - 51 Protein_320 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T264984 WP_003401566.1 NZ_CP112996:365112-365537 [Mycobacterium tuberculosis variant bovis]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT264984 WP_003401563.1 NZ_CP112996:364894-365115 [Mycobacterium tuberculosis variant bovis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
PDB 3H87
AlphaFold DB A0A829CG48

References