Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3736738..3737395 Replicon chromosome
Accession NZ_CP112980
Organism Enterobacter hormaechei subsp. xiangfangensis strain CNCI 7

Toxin (Protein)


Gene name cptA Uniprot ID A0A837FG63
Locus tag MTX27_RS17855 Protein ID WP_003863439.1
Coordinates 3736738..3737148 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag MTX27_RS17860 Protein ID WP_003863437.1
Coordinates 3737129..3737395 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTX27_RS17835 (MTX27_17830) 3732736..3734469 - 1734 WP_022651808.1 single-stranded-DNA-specific exonuclease RecJ -
MTX27_RS17840 (MTX27_17835) 3734475..3735188 - 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MTX27_RS17845 (MTX27_17840) 3735217..3736113 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
MTX27_RS17850 (MTX27_17845) 3736215..3736736 + 522 WP_003863440.1 flavodoxin FldB -
MTX27_RS17855 (MTX27_17850) 3736738..3737148 - 411 WP_003863439.1 protein YgfX Toxin
MTX27_RS17860 (MTX27_17855) 3737129..3737395 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
MTX27_RS17865 (MTX27_17860) 3737690..3738670 + 981 WP_100154205.1 tRNA-modifying protein YgfZ -
MTX27_RS17870 (MTX27_17865) 3738756..3739415 - 660 WP_003863433.1 hemolysin III family protein -
MTX27_RS17875 (MTX27_17870) 3739682..3740413 + 732 WP_003863431.1 MurR/RpiR family transcriptional regulator -
MTX27_RS17880 (MTX27_17875) 3740530..3741963 + 1434 WP_003863430.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16339.24 Da        Isoelectric Point: 11.4775

>T264979 WP_003863439.1 NZ_CP112980:c3737148-3736738 [Enterobacter hormaechei subsp. xiangfangensis]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT264979 WP_003863437.1 NZ_CP112980:c3737395-3737129 [Enterobacter hormaechei subsp. xiangfangensis]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FG63

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References