Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA(toxin)
Location 2988391..2990174 Replicon chromosome
Accession NZ_CP112980
Organism Enterobacter hormaechei subsp. xiangfangensis strain CNCI 7

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag MTX27_RS14320 Protein ID WP_023314540.1
Coordinates 2988391..2989740 (+) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A837FFV9
Locus tag MTX27_RS14325 Protein ID WP_003859317.1
Coordinates 2989737..2990174 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTX27_RS14295 (MTX27_14290) 2984214..2985149 - 936 WP_045337652.1 tRNA dihydrouridine(16) synthase DusC -
MTX27_RS14300 (MTX27_14295) 2985318..2985713 + 396 WP_003859308.1 CidA/LrgA family protein -
MTX27_RS14305 (MTX27_14300) 2985710..2986405 + 696 WP_003859310.1 CidB/LrgB family autolysis modulator -
MTX27_RS14310 (MTX27_14305) 2986534..2987418 + 885 WP_003859312.1 cytidine deaminase -
MTX27_RS14315 (MTX27_14310) 2987546..2988256 + 711 WP_003859314.1 outer membrane permeability protein SanA -
MTX27_RS14320 (MTX27_14315) 2988391..2989740 + 1350 WP_023314540.1 HipA domain-containing protein Toxin
MTX27_RS14325 (MTX27_14320) 2989737..2990174 + 438 WP_003859317.1 helix-turn-helix transcriptional regulator Antitoxin
MTX27_RS14330 (MTX27_14325) 2990213..2991223 - 1011 WP_003859318.1 galactose/methyl galactoside ABC transporter permease MglC -
MTX27_RS14335 (MTX27_14330) 2991239..2992759 - 1521 WP_003859320.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
MTX27_RS14340 (MTX27_14335) 2992839..2993837 - 999 WP_003859322.1 galactose/glucose ABC transporter substrate-binding protein MglB -
MTX27_RS14345 (MTX27_14340) 2994133..2995155 - 1023 WP_003859324.1 HTH-type transcriptional regulator GalS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-406)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 51137.78 Da        Isoelectric Point: 4.6562

>T264977 WP_023314540.1 NZ_CP112980:2988391-2989740 [Enterobacter hormaechei subsp. xiangfangensis]
METLTVQAYLNETWTDIALIKYPGSEKNDWNTTQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDHGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNKFASTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVETMR
LEEGSHYPSLWLPRFDIVRNEQDQLVRLGMESVYSLLQKAPGTLLDHETTLRALINKITSSHMVQQQGYHFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENQIMLSPVYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNTIAQTLAEWIPPAT
LLDALHETAVQLIDLPERLAARGVPEQIMEMPAMGFRYIPDKLSRWGLL

Download         Length: 1350 bp

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 16185.64 Da        Isoelectric Point: 10.5154

>AT264977 WP_003859317.1 NZ_CP112980:2989737-2990174 [Enterobacter hormaechei subsp. xiangfangensis]
MKTPNEAESELLQTLAQVRSVNKKRHHDEAEEPDKPSVVKRQRVTQGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADVINKIFKPFGLQTGLVPVSKSLIASLFS

Download         Length: 438 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A837FFV9

References