Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2279926..2280665 Replicon chromosome
Accession NZ_CP112980
Organism Enterobacter hormaechei subsp. xiangfangensis strain CNCI 7

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag MTX27_RS10965 Protein ID WP_003857133.1
Coordinates 2279926..2280411 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag MTX27_RS10970 Protein ID WP_003857131.1
Coordinates 2280399..2280665 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTX27_RS10945 (MTX27_10940) 2274928..2275686 + 759 WP_003857136.1 DeoR/GlpR family DNA-binding transcription regulator -
MTX27_RS10950 (MTX27_10945) 2275791..2277083 + 1293 WP_045896810.1 glycosyl hydrolase family 28 protein -
MTX27_RS10955 (MTX27_10950) 2277628..2278775 + 1148 WP_095429518.1 IS3 family transposase -
MTX27_RS10960 (MTX27_10955) 2278868..2279464 - 597 Protein_2137 IS3 family transposase -
MTX27_RS10965 (MTX27_10960) 2279926..2280411 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
MTX27_RS10970 (MTX27_10965) 2280399..2280665 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
MTX27_RS10975 (MTX27_10970) 2280729..2281658 - 930 WP_022651200.1 LysR family transcriptional regulator -
MTX27_RS10980 (MTX27_10975) 2281788..2283176 + 1389 WP_063401776.1 MFS transporter -
MTX27_RS10985 (MTX27_10980) 2283198..2284193 - 996 WP_023314163.1 DUF2891 domain-containing protein -
MTX27_RS10990 (MTX27_10985) 2284203..2285189 - 987 WP_003857123.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T264972 WP_003857133.1 NZ_CP112980:c2280411-2279926 [Enterobacter hormaechei subsp. xiangfangensis]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT264972 WP_003857131.1 NZ_CP112980:c2280665-2280399 [Enterobacter hormaechei subsp. xiangfangensis]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References