264969

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2481836..2482464 Replicon chromosome
Accession NZ_CP112978
Organism Leptospira borgpetersenii strain I-3

Toxin (Protein)


Gene name vapC Uniprot ID M6E4U3
Locus tag OR565_RS10655 Protein ID WP_002724218.1
Coordinates 2482063..2482464 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag OR565_RS10650 Protein ID WP_010705987.1
Coordinates 2481836..2482066 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OR565_RS10635 (OR565_10635) 2479809..2480507 - 699 WP_002724172.1 hypothetical protein -
OR565_RS10640 (OR565_10640) 2480690..2480918 - 229 Protein_2098 hypothetical protein -
OR565_RS10645 (OR565_10645) 2481433..2481570 - 138 WP_002736206.1 hypothetical protein -
OR565_RS10650 (OR565_10650) 2481836..2482066 + 231 WP_010705987.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
OR565_RS10655 (OR565_10655) 2482063..2482464 + 402 WP_002724218.1 type II toxin-antitoxin system VapC family toxin Toxin
OR565_RS10660 (OR565_10660) 2482610..2482789 - 180 WP_002724268.1 hypothetical protein -
OR565_RS10665 (OR565_10665) 2482899..2484581 - 1683 WP_002724258.1 dihydroxy-acid dehydratase -
OR565_RS10670 (OR565_10670) 2484990..2485535 + 546 WP_170874669.1 metal-dependent hydrolase -
OR565_RS10675 (OR565_10675) 2486328..2486618 + 291 WP_002736220.1 YciI family protein -
OR565_RS10680 (OR565_10680) 2486627..2487323 - 697 Protein_2106 adenylate/guanylate cyclase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15501.23 Da        Isoelectric Point: 9.9288

>T264969 WP_002724218.1 NZ_CP112978:2482063-2482464 [Leptospira borgpetersenii]
MTQYLLDTNICIYIINQKPRSVYKKFKKIKLENIFISSITEFELKYGVQKSLHFERNLKILEEFLSYLNILSFVSEDANK
AAKIRVELDKVGKPIGPFDLLIASQALSNKLTLVTNNEKEFTRIKDIKIANWL

Download         Length: 402 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8947.11 Da        Isoelectric Point: 10.1326

>AT264969 WP_010705987.1 NZ_CP112978:2481836-2482066 [Leptospira borgpetersenii]
MNKAKIFKNGDSQAIRLPKDYRFKGKEVYIRRDGDNVILTPINDAVDRFWNTVNSFSDDLILDRNQPNEYGKRNKI

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M6E4U3

Antitoxin

Source ID Structure

References