Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpIK/PemK(toxin)
Location 539955..540531 Replicon chromosome
Accession NZ_CP112976
Organism Leptospira kirschneri strain I-7

Toxin (Protein)


Gene name chpK Uniprot ID A0A828YA21
Locus tag ORQ95_RS02265 Protein ID WP_004755078.1
Coordinates 540190..540531 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name chpI Uniprot ID A0A828Y9A4
Locus tag ORQ95_RS02260 Protein ID WP_004759478.1
Coordinates 539955..540203 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORQ95_RS02250 (ORQ95_02250) 536434..537216 + 783 WP_004754327.1 ABC transporter ATP-binding protein -
ORQ95_RS02255 (ORQ95_02255) 537213..539750 + 2538 WP_004759514.1 FtsX-like permease family protein -
ORQ95_RS02260 (ORQ95_02260) 539955..540203 + 249 WP_004759478.1 hypothetical protein Antitoxin
ORQ95_RS02265 (ORQ95_02265) 540190..540531 + 342 WP_004755078.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
ORQ95_RS02270 (ORQ95_02270) 540638..540787 + 150 WP_004759513.1 hypothetical protein -
ORQ95_RS02275 (ORQ95_02275) 541604..541891 - 288 WP_004754874.1 hypothetical protein -
ORQ95_RS02280 (ORQ95_02280) 542321..542869 - 549 WP_004754121.1 YqgE/AlgH family protein -
ORQ95_RS02285 (ORQ95_02285) 542893..543861 - 969 WP_004755369.1 Gfo/Idh/MocA family oxidoreductase -
ORQ95_RS02290 (ORQ95_02290) 544137..545255 - 1119 WP_004760477.1 molecular chaperone DnaJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12354.23 Da        Isoelectric Point: 5.1486

>T264966 WP_004755078.1 NZ_CP112976:540190-540531 [Leptospira kirschneri]
MIRGEIWWVDLGIPFGSEPGFKRPVLIIQDDSFNQSNISTVVSIAITSNLNLSEAPGNVLIGKKESSLSKDSVVNVSQIV
TLDKERFIERVGKLKSSKINEVEVGLKLVTGLD

Download         Length: 342 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9422.94 Da        Isoelectric Point: 10.4447

>AT264966 WP_004759478.1 NZ_CP112976:539955-540203 [Leptospira kirschneri]
MKTAISIPDELFKTAEKTAKKLGIPRSQLFAKALEEFIQSHSKESVTEKLNKIYNRKSKELKSNITDLSVELLRKSLKND
SW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828YA21

Antitoxin

Source ID Structure
AlphaFold DB A0A828Y9A4

References