Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/Txe-RelB
Location 124492..124999 Replicon chromosome
Accession NZ_CP112971
Organism Rickettsia conorii subsp. heilongjiangensis strain B8

Toxin (Protein)


Gene name relB Uniprot ID -
Locus tag OSR38_RS00665 Protein ID WP_267185184.1
Coordinates 124492..124755 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID G4KM09
Locus tag OSR38_RS00670 Protein ID WP_014013838.1
Coordinates 124748..124999 (-) Length 84 a.a.

Genomic Context

OSR38_RS00640OSR38_RS00645OSR38_RS00675OSR38_RS00680OSR38_RS00685OSR38_RS00690OSR38_RS00695OSR38_RS00700OSR38_RS00650OSR38_RS00655OSR38_RS00660OSR38_RS00665OSR38_RS00670
Location: 119997..120179 (183 bp)
Type: Others
Protein ID: WP_267185181.1
Location: 120302..120925 (624 bp)
Type: Others
Protein ID: WP_267185182.1
Location: 125139..126143 (1005 bp)
Type: Others
Protein ID: WP_267185185.1
Location: 126148..126903 (756 bp)
Type: Others
Protein ID: WP_014013840.1
Location: 126923..127522 (600 bp)
Type: Others
Protein ID: WP_267185186.1
Location: 127746..128033 (288 bp)
Type: Others
Protein ID: WP_045805280.1
Location: 128263..128610 (348 bp)
Type: Others
Protein ID: WP_267185525.1
Location: 128744..129811 (1068 bp)
Type: Others
Protein ID: WP_014013842.1
Location: 121029..122423 (1395 bp)
Type: Others
Protein ID: WP_014120498.1
Location: 122420..123076 (657 bp)
Type: Others
Protein ID: WP_267185183.1
Location: 123227..124432 (1206 bp)
Type: Others
Protein ID: WP_014013836.1
Location: 124492..124755 (264 bp)
Type: Toxin
Protein ID: WP_267185184.1
Location: 124748..124999 (252 bp)
Type: Antitoxin
Protein ID: WP_014013838.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
OSR38_RS00640 (OSR38_00640)119997..120179+183WP_267185181.1hypothetical protein-
OSR38_RS00645 (OSR38_00645)120302..120925+624WP_267185182.1hypothetical protein-
OSR38_RS00650 (OSR38_00650)121029..122423-1395WP_014120498.1lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase-
OSR38_RS00655 (OSR38_00655)122420..123076-657WP_267185183.1lysophospholipid acyltransferase family protein-
OSR38_RS00660 (OSR38_00660)123227..124432-1206WP_014013836.1pyridoxal phosphate-dependent aminotransferase-
OSR38_RS00665 (OSR38_00665)124492..124755-264WP_267185184.1Txe/YoeB family addiction module toxinToxin
OSR38_RS00670 (OSR38_00670)124748..124999-252WP_014013838.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
OSR38_RS00675 (OSR38_00675)125139..126143+1005WP_267185185.1methyltransferase domain-containing protein-
OSR38_RS00680 (OSR38_00680)126148..126903+756WP_014013840.1VacJ family lipoprotein-
OSR38_RS00685 (OSR38_00685)126923..127522+600WP_267185186.1phospholipid-binding protein MlaC-
OSR38_RS00690 (OSR38_00690)127746..128033+288WP_045805280.1ribose-phosphate pyrophosphokinase-like domain-containing protein-
OSR38_RS00695 (OSR38_00695)128263..128610+348WP_267185525.1phosphoribosyltransferase family protein-
OSR38_RS00700 (OSR38_00700)128744..129811+1068WP_014013842.1alanine racemase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10580.35 Da        Isoelectric Point: 9.8255

>T264964 WP_267185184.1 NZ_CP112971:c124755-124492 [Rickettsia conorii subsp. heilongjiangensis]
MIEIEWTLEAAEDLVYWKKYDIKKYERIKLLIKNIQEASFTGIGKPESLKHILSGLWSRRINHEHRLIYSVNTKQIIIYN
CRFHYKN

Download         Length: 264 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9537.81 Da        Isoelectric Point: 9.4884

>AT264964 WP_014013838.1 NZ_CP112971:c124999-124748 [Rickettsia conorii subsp. heilongjiangensis]
MNSISGTSFRKNLSSVLNTVENDHVPYLIKRKNHKNIILLTEEEYESTKETLYLLSNLANANRIKKSIEQAKRGEFAKVN
LDD

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A6H3RZ38

References