Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4144152..4144771 Replicon chromosome
Accession NZ_CP112887
Organism Raoultella electrica strain S2-IND-01-C

Toxin (Protein)


Gene name Hha Uniprot ID A0A514EV16
Locus tag OR613_RS20165 Protein ID WP_004858783.1
Coordinates 4144553..4144771 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A514EV88
Locus tag OR613_RS20160 Protein ID WP_004858785.1
Coordinates 4144152..4144526 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OR613_RS20150 (OR613_20150) 4139264..4140457 + 1194 WP_100683172.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
OR613_RS20155 (OR613_20155) 4140480..4143626 + 3147 WP_131047523.1 multidrug efflux RND transporter permease subunit AcrB -
OR613_RS20160 (OR613_20160) 4144152..4144526 + 375 WP_004858785.1 Hha toxicity modulator TomB Antitoxin
OR613_RS20165 (OR613_20165) 4144553..4144771 + 219 WP_004858783.1 HHA domain-containing protein Toxin
OR613_RS20170 (OR613_20170) 4144923..4145489 + 567 WP_131047522.1 maltose O-acetyltransferase -
OR613_RS20175 (OR613_20175) 4145589..4146059 + 471 WP_100683169.1 YlaC family protein -
OR613_RS20180 (OR613_20180) 4146034..4147479 - 1446 WP_131047521.1 PLP-dependent aminotransferase family protein -
OR613_RS20185 (OR613_20185) 4147590..4148300 + 711 WP_131047520.1 GNAT family protein -
OR613_RS20190 (OR613_20190) 4148297..4148437 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
OR613_RS20195 (OR613_20195) 4148437..4148700 - 264 WP_100683166.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8570.90 Da        Isoelectric Point: 7.9907

>T264951 WP_004858783.1 NZ_CP112887:4144553-4144771 [Raoultella electrica]
MSGEPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14411.19 Da        Isoelectric Point: 4.8989

>AT264951 WP_004858785.1 NZ_CP112887:4144152-4144526 [Raoultella electrica]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYAEDNKLIAQLDEYL
DDTFMLFSSYGINTADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A514EV16

Antitoxin

Source ID Structure
AlphaFold DB A0A514EV88

References