Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2706648..2708239 Replicon chromosome
Accession NZ_CP112887
Organism Raoultella electrica strain S2-IND-01-C

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OR613_RS13235 Protein ID WP_131049089.1
Coordinates 2706648..2707967 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OR613_RS13240 Protein ID WP_131049088.1
Coordinates 2707967..2708239 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OR613_RS13220 (OR613_13225) 2702541..2703455 - 915 WP_131049091.1 branched-chain amino acid ABC transporter permease LivH -
OR613_RS13225 (OR613_13230) 2703546..2704604 - 1059 WP_206057711.1 branched-chain amino acid ABC transporter substrate-binding protein -
OR613_RS13230 (OR613_13235) 2705309..2706703 + 1395 WP_131049115.1 glycoside hydrolase family 10 protein -
OR613_RS13235 (OR613_13240) 2706648..2707967 - 1320 WP_131049089.1 type II toxin-antitoxin system HipA family toxin Toxin
OR613_RS13240 (OR613_13245) 2707967..2708239 - 273 WP_131049088.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OR613_RS13245 (OR613_13250) 2708445..2708999 - 555 WP_100684220.1 sigma-70 family RNA polymerase sigma factor -
OR613_RS13250 (OR613_13255) 2709005..2709421 - 417 WP_131049087.1 hypothetical protein -
OR613_RS13255 (OR613_13260) 2709541..2710782 - 1242 WP_131049086.1 sensor domain-containing diguanylate cyclase -
OR613_RS13260 (OR613_13265) 2711334..2712026 + 693 WP_100684223.1 TenA family protein -
OR613_RS13265 (OR613_13270) 2712023..2712751 + 729 WP_165457169.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-68)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49045.37 Da        Isoelectric Point: 7.4738

>T264950 WP_131049089.1 NZ_CP112887:c2707967-2706648 [Raoultella electrica]
MATLVTWMNNERVGELIKQANGAHLFRYEEAWMRNPRARPLSLSLPLQYGNITDEAVFNYFDNLLPDSPRVRDRIVKRYR
ARSKQPFDLLAEIGRDSVGAVTLLPPGENAPRGALSWEPLDNHALDALLTAYRSDIPLGMVNEHDDFRISVAGAQEKTAL
LKIGEQWCIPTGTTPTTHIIKLPIGEIKQPDAVLDLSESVDNEYLCLALARALGFAVPQASIIQTASTRALAVERFDRRW
AQEKTVLLRLPQEDLCQAFGIPSSVKYESDGGPGIRAIMAFLVGSSEALEDRYNFMKFMVFQWLIGATDGHAKNFSIYLQ
PGGSYRLTPFYDIISAFPLLGGKGLHLSDLKLSMSLKASKGRKTEIQTLYPRHFLATAKEVGFARPQMLEILRYFVDNVP
RAVDAVKGTLPPDFSQPVYEAITDRLLWVHSRLQNAMAG

Download         Length: 1320 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10264.61 Da        Isoelectric Point: 6.9745

>AT264950 WP_131049088.1 NZ_CP112887:c2708239-2707967 [Raoultella electrica]
MSPSPTIYSPVQLANYLKLVRQKNQWTQSDLAQRMGIKQATVSNFENHPEKTTLTTVFKILQSLELSMVICEKNAPDSGN
NRDNPQDLDW

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References