Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1898815..1899405 Replicon chromosome
Accession NZ_CP112887
Organism Raoultella electrica strain S2-IND-01-C

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag OR613_RS08970 Protein ID WP_131050468.1
Coordinates 1899073..1899405 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A3S7DDD0
Locus tag OR613_RS08965 Protein ID WP_000288812.1
Coordinates 1898815..1899072 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OR613_RS08950 (OR613_08950) 1896088..1896228 - 141 WP_160702628.1 hypothetical protein -
OR613_RS08955 (OR613_08955) 1896970..1898079 + 1110 WP_131050467.1 dimethyl sulfone monooxygenase SfnG -
OR613_RS08960 (OR613_08965) 1898274..1898465 + 192 WP_131050504.1 helix-turn-helix domain-containing protein -
OR613_RS08965 (OR613_08970) 1898815..1899072 + 258 WP_000288812.1 antitoxin Antitoxin
OR613_RS08970 (OR613_08975) 1899073..1899405 + 333 WP_131050468.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OR613_RS08980 (OR613_08985) 1899642..1900442 - 801 WP_160702622.1 DgsA anti-repressor MtfA -
OR613_RS08990 (OR613_08995) 1900872..1901036 + 165 Protein_1755 IS3 family transposase -
OR613_RS08995 (OR613_09000) 1901127..1902197 - 1071 WP_131050765.1 porin -
OR613_RS09000 (OR613_09005) 1902788..1903069 + 282 WP_100682246.1 cell division protein DrpB -
OR613_RS09005 (OR613_09010) 1903112..1903807 + 696 WP_131050764.1 phosphohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11823.72 Da        Isoelectric Point: 9.4903

>T264943 WP_131050468.1 NZ_CP112887:1899073-1899405 [Raoultella electrica]
MDRGEIWLVSLDPIAGHEQCGKRPVLIVSQASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEGAGTKTIGVIRCDQPRTI
DMAARNGKRLERIPDAVVNEVLARLDAILS

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9442.92 Da        Isoelectric Point: 4.3566

>AT264943 WP_000288812.1 NZ_CP112887:1898815-1899072 [Raoultella electrica]
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKEIL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3S7DDD0

References