Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 5480016..5480580 Replicon chromosome
Accession NZ_CP112880
Organism Streptomyces sp. CA-278952

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag N7925_RS24520 Protein ID WP_265601608.1
Coordinates 5480233..5480580 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag N7925_RS24515 Protein ID WP_228182779.1
Coordinates 5480016..5480246 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7925_RS24500 (N7925_24510) 5475057..5475965 + 909 WP_274345176.1 LysR family transcriptional regulator -
N7925_RS24505 (N7925_24515) 5476031..5477185 + 1155 WP_274345177.1 allantoicase -
N7925_RS24510 (N7925_24520) 5477336..5479912 - 2577 WP_265601607.1 aminopeptidase N -
N7925_RS24515 (N7925_24525) 5480016..5480246 + 231 WP_228182779.1 ribbon-helix-helix domain-containing protein Antitoxin
N7925_RS24520 (N7925_24530) 5480233..5480580 + 348 WP_265601608.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
N7925_RS24525 (N7925_24535) 5480653..5481681 - 1029 WP_265601609.1 aspartate-semialdehyde dehydrogenase -
N7925_RS24530 (N7925_24540) 5481986..5485294 - 3309 WP_265601610.1 S8 family serine peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-38)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12746.60 Da        Isoelectric Point: 10.4132

>T264937 WP_265601608.1 NZ_CP112880:5480233-5480580 [Streptomyces sp. CA-278952]
MRRGDIYLVDYEPVRDSEANKARPSIIVSNDGANAAVDRAGRGVVTVVPLTSNVSRLYPFQVLLQAGDSGLAKDSKVQCE
QVRAMAQERFVRQIGRVPRQRMAEIDAALRRHLAL

Download         Length: 348 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8385.14 Da        Isoelectric Point: 3.8382

>AT264937 WP_228182779.1 NZ_CP112880:5480016-5480246 [Streptomyces sp. CA-278952]
MKISVSLPQEDVAFVDEYATKTEADSRSAVIHAAIELLRASNLEADYVAAFAEWDESEDAAFWDKFSGDGIVDEAR

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References