Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 2479376..2479986 Replicon chromosome
Accession NZ_CP112868
Organism Pseudomonas quebecensis isolate S1Bt3

Toxin (Protein)


Gene name hicA Uniprot ID A0A2G0WYT7
Locus tag OSC49_RS11455 Protein ID WP_034096965.1
Coordinates 2479735..2479986 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OSC49_RS11450 Protein ID WP_181077070.1
Coordinates 2479376..2479738 (-) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSC49_RS11435 (OSC49_11435) 2475468..2476298 + 831 WP_253506786.1 IclR family transcriptional regulator -
OSC49_RS11440 (OSC49_11440) 2476522..2477721 + 1200 WP_266248926.1 hypothetical protein -
OSC49_RS11445 (OSC49_11445) 2477872..2479227 + 1356 WP_181077068.1 MATE family efflux transporter -
OSC49_RS11450 (OSC49_11450) 2479376..2479738 - 363 WP_181077070.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OSC49_RS11455 (OSC49_11455) 2479735..2479986 - 252 WP_034096965.1 type II toxin-antitoxin system HicA family toxin Toxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9497.05 Da        Isoelectric Point: 10.0458

>T264897 WP_034096965.1 NZ_CP112868:c2479986-2479735 [Pseudomonas quebecensis]
VSKNEKLLAKLLNEQMAFTWPELVTLLRRLGYTQIEGAGSRVKFDSGDPTAMITLHKPHPGNELKHYIRRQIIEQLKSGE
LIQ

Download         Length: 252 bp

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 13248.06 Da        Isoelectric Point: 6.7446

>AT264897 WP_181077070.1 NZ_CP112868:c2479738-2479376 [Pseudomonas quebecensis]
VNNQLKHKGYIGSIEASLEDNCLFGKILFIKALISYEGKTVADLDAAFQEAVDDYLVTCQNLGQTPEKPCKGSFNVRVGH
DLHLAAALAATRRKVTLNDLTRQALNEFLQHHFAELHPSA

Download         Length: 363 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G0WYT7

Antitoxin

Source ID Structure

References