Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 222048..222577 Replicon chromosome
Accession NZ_CP112862
Organism Enterococcus faecium strain DVT1681

Toxin (Protein)


Gene name relE Uniprot ID Q3XX67
Locus tag OSG99_RS01095 Protein ID WP_002296560.1
Coordinates 222311..222577 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A829F3T0
Locus tag OSG99_RS01090 Protein ID WP_002296559.1
Coordinates 222048..222311 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSG99_RS01080 (OSG99_01080) 219422..221245 + 1824 WP_002294202.1 APC family permease -
OSG99_RS01085 (OSG99_01085) 221387..221572 - 186 WP_002296558.1 transcriptional regulator -
OSG99_RS01090 (OSG99_01090) 222048..222311 + 264 WP_002296559.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OSG99_RS01095 (OSG99_01095) 222311..222577 + 267 WP_002296560.1 Txe/YoeB family addiction module toxin Toxin
OSG99_RS01100 (OSG99_01100) 222778..223266 + 489 WP_002296561.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
OSG99_RS01105 (OSG99_01105) 223807..224460 - 654 WP_002323018.1 ABC transporter permease -
OSG99_RS01110 (OSG99_01110) 224475..225392 - 918 WP_002296564.1 osmoprotectant ABC transporter substrate-binding protein -
OSG99_RS01115 (OSG99_01115) 225389..226030 - 642 WP_002293405.1 ABC transporter permease -
OSG99_RS01120 (OSG99_01120) 226034..227209 - 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(M) / tet(L) lap / bopD 190876..386740 195864


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10660.13 Da        Isoelectric Point: 9.9931

>T264889 WP_002296560.1 NZ_CP112862:222311-222577 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQTNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10046.05 Da        Isoelectric Point: 4.1207

>AT264889 WP_002296559.1 NZ_CP112862:222048-222311 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSSFTNID
DIDWEAL

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FCW8

Antitoxin

Source ID Structure
AlphaFold DB A0A829F3T0

References