264878

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2271715..2273471 Replicon chromosome
Accession NZ_CP111140
Organism Burkholderia pseudomallei strain MSHR1046

Toxin (Protein)


Gene name doc Uniprot ID B1H5R2
Locus tag OSB54_RS09455 Protein ID WP_004524002.1
Coordinates 2272566..2273471 (-) Length 302 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q63LW2
Locus tag OSB54_RS09450 Protein ID WP_004195450.1
Coordinates 2271715..2272569 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSB54_RS09430 (OSB54_09430) 2266931..2268421 - 1491 WP_004524006.1 aldehyde dehydrogenase -
OSB54_RS09435 (OSB54_09435) 2268447..2269262 - 816 WP_004524005.1 aspartate dehydrogenase -
OSB54_RS09440 (OSB54_09440) 2269255..2270928 - 1674 WP_004524004.1 thiamine pyrophosphate-binding protein -
OSB54_RS09445 (OSB54_09445) 2270921..2271718 - 798 WP_004524003.1 SDR family oxidoreductase -
OSB54_RS09450 (OSB54_09450) 2271715..2272569 - 855 WP_004195450.1 IclR family transcriptional regulator Antitoxin
OSB54_RS09455 (OSB54_09455) 2272566..2273471 - 906 WP_004524002.1 alpha/beta fold hydrolase Toxin
OSB54_RS09460 (OSB54_09460) 2273488..2274015 - 528 WP_004524001.1 cupin domain-containing protein -
OSB54_RS09465 (OSB54_09465) 2274054..2274824 - 771 WP_004524000.1 SDR family oxidoreductase -
OSB54_RS09470 (OSB54_09470) 2274821..2275888 - 1068 WP_004523999.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
OSB54_RS09475 (OSB54_09475) 2275923..2276234 - 312 WP_004184841.1 hypothetical protein -
OSB54_RS09480 (OSB54_09480) 2276236..2276553 - 318 WP_004184916.1 non-heme iron oxygenase ferredoxin subunit -
OSB54_RS09485 (OSB54_09485) 2276988..2278076 + 1089 WP_004523998.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(54-284)

Antitoxin

Transcription regulator IclR, C-terminal

(143-265)


Sequences

Toxin        


Download         Length: 302 a.a.        Molecular weight: 30556.69 Da        Isoelectric Point: 8.4944

>T264878 WP_004524002.1 NZ_CP111140:c2273471-2272566 [Burkholderia pseudomallei]
MSTISTTTTEAGAAPFAALLARFPERRAAVGGAGVIGYREAGEAHARRAGCEPVVLLHGIGSGAASWVRQLDALGATRRA
LAWDAPGYGASSRVAADSPVAADYAASLAAWLDALRIERCVLVGHSLGAIMAGAFARIAGERLAGLLLISPAGGYGSAPA
DVRAGRRDSRLALLASLGPQGLAAERSANMLSAQASGAAREWVRWNMARIAPAGYAQATHLLANADLASDLAHCRGRIAV
AVGGDDAITPPAACERIARAAGVGLQVIARAGHAGYVEAPDAYSALIDAFCRQCDGSRGTP

Download         Length: 906 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31152.56 Da        Isoelectric Point: 6.8932

>AT264878 WP_004195450.1 NZ_CP111140:c2272569-2271715 [Burkholderia pseudomallei]
MSEPLLKDADDARNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTAHIVIRDGRDVVFVAKAQNAGNAFGSVRVNVGTRLPAHATTHGHV
LMGDLSLAQLRALYPERALERVTKATPETVDALFDVIRDDARRGYGIGNSAFERDISVVTAPVRNEASRIVAVVTVTVPR
PEIDAALVAEGLVEKVVRAAAELSRRLNYRSDDENTYLKALGLR

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A095K1W1

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4FRW8

References