Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1495981..1497740 Replicon chromosome
Accession NZ_CP111140
Organism Burkholderia pseudomallei strain MSHR1046

Toxin (Protein)


Gene name hipA Uniprot ID B1H781
Locus tag OSB54_RS06440 Protein ID WP_004525276.1
Coordinates 1495981..1497333 (-) Length 451 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0F6L1Y8
Locus tag OSB54_RS06445 Protein ID WP_004525277.1
Coordinates 1497330..1497740 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSB54_RS06420 (OSB54_06420) 1492277..1492618 - 342 WP_004525272.1 hypothetical protein -
OSB54_RS06425 (OSB54_06425) 1492892..1493845 - 954 WP_004187785.1 agmatinase -
OSB54_RS06430 (OSB54_06430) 1494012..1494926 + 915 WP_004525274.1 LysR family transcriptional regulator -
OSB54_RS06435 (OSB54_06435) 1495361..1495813 + 453 WP_004198842.1 hypothetical protein -
OSB54_RS06440 (OSB54_06440) 1495981..1497333 - 1353 WP_004525276.1 type II toxin-antitoxin system HipA family toxin Toxin
OSB54_RS06445 (OSB54_06445) 1497330..1497740 - 411 WP_004525277.1 helix-turn-helix domain-containing protein Antitoxin
OSB54_RS06450 (OSB54_06450) 1498078..1498341 - 264 WP_004199789.1 hypothetical protein -
OSB54_RS06455 (OSB54_06455) 1498806..1501202 + 2397 WP_052115519.1 cellulose biosynthesis cyclic di-GMP-binding regulatory protein BcsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1489624..1498789 9165


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(158-406)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-71)


Sequences

Toxin        


Download         Length: 451 a.a.        Molecular weight: 49790.80 Da        Isoelectric Point: 9.8300

>T264877 WP_004525276.1 NZ_CP111140:c1497333-1495981 [Burkholderia pseudomallei]
VSARRARATRLHLWMNGLPVGYWEHARDGERLVYFDEWIGDPQGRPLSLSLPFTPGNQPYRGRLVSDYFDNLLPDSEPIR
RRIAMRYRTGGTSAFALLATLGRDCVGALQMLPPDEAPDDIERIRGHALADADIARLLREVTSAPQAGRHAPLDDLRLSI
AGAQEKTALLRHRGRWLLPEGSTPTTHILKLPLGLVGNRRADMRTSVENEWLCARIVAAYGLPVARCDIAQFDDQKALVV
ERFDRRPSRDARWLLRLPQEDMCQATGTSALDKYQADGGPGIETIMEVLAGSEHARDDRRAFFAAQIVFWLLAATDGHAK
NFSIAHLPGNRYRSTPLYDVLSAHPVIGRGANQLPAQRARLAMGVRGKHIHYPLHQIRRRHWIAQGQRVGFAPADVDALI
DTLTARTAGVVDAVSARLPRDFPRDVADAIFSGMLGLSARLAGDAAARAP

Download         Length: 1353 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14480.82 Da        Isoelectric Point: 11.8540

>AT264877 WP_004525277.1 NZ_CP111140:c1497740-1497330 [Burkholderia pseudomallei]
MAILIEHEIKTLGQLRPILRGFRKSAGLTQAMLASRLGVTQQTYAQFEANPASASVERLFKVLRALDIELTLTLTQVYAA
PAGKDKGEVAKTAAGARARAGARRAAPPASAPAPSAAGRAPRPARKRAAPKKREDW

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K3EM91

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6L1Y8

References