Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 3923473..3924128 Replicon chromosome
Accession NZ_CP111139
Organism Burkholderia pseudomallei strain MSHR1713

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag OSB35_RS30390 Protein ID WP_004521942.1
Coordinates 3923832..3924128 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q63YL3
Locus tag OSB35_RS30385 Protein ID WP_004202809.1
Coordinates 3923473..3923829 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSB35_RS30355 (OSB35_30355) 3919599..3920357 + 759 WP_004521940.1 cytochrome c1 -
OSB35_RS30360 (OSB35_30360) 3920450..3921061 + 612 WP_004185176.1 glutathione S-transferase N-terminal domain-containing protein -
OSB35_RS30365 (OSB35_30365) 3921131..3921658 + 528 WP_004521941.1 ClpXP protease specificity-enhancing factor -
OSB35_RS30375 (OSB35_30375) 3921994..3922377 + 384 WP_044584020.1 terminase -
OSB35_RS30380 (OSB35_30380) 3922374..3923429 + 1056 WP_004557286.1 phage portal protein -
OSB35_RS30385 (OSB35_30385) 3923473..3923829 - 357 WP_004202809.1 putative addiction module antidote protein Antitoxin
OSB35_RS30390 (OSB35_30390) 3923832..3924128 - 297 WP_004521942.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OSB35_RS30395 (OSB35_30395) 3924796..3926052 + 1257 WP_004552667.1 AAA family ATPase -
OSB35_RS30400 (OSB35_30400) 3926097..3926672 + 576 WP_198014201.1 DUF4276 family protein -
OSB35_RS30405 (OSB35_30405) 3927426..3927770 + 345 WP_004535737.1 hypothetical protein -
OSB35_RS30410 (OSB35_30410) 3927763..3928174 + 412 Protein_3493 phage tail protein I -
OSB35_RS30415 (OSB35_30415) 3928213..3928674 + 462 WP_232290550.1 DNA methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3922063..3930130 8067


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10902.68 Da        Isoelectric Point: 9.9369

>T264876 WP_004521942.1 NZ_CP111139:c3924128-3923832 [Burkholderia pseudomallei]
MFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKLAKQIADELED

Download         Length: 297 bp

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12585.41 Da        Isoelectric Point: 9.9470

>AT264876 WP_004202809.1 NZ_CP111139:c3923829-3923473 [Burkholderia pseudomallei]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4G1D3

References