264875

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT_toxin-BrnA
Location 2975738..2976275 Replicon chromosome
Accession NZ_CP111138
Organism Burkholderia pseudomallei strain MSHR1713

Toxin (Protein)


Gene name brnT Uniprot ID A0A2K9CXB8
Locus tag OSB35_RS12425 Protein ID WP_004557717.1
Coordinates 2976006..2976275 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID Q63NA3
Locus tag OSB35_RS12420 Protein ID WP_004525420.1
Coordinates 2975738..2976022 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSB35_RS12395 (OSB35_12395) 2970846..2972216 - 1371 WP_004525424.1 cytochrome c peroxidase -
OSB35_RS12400 (OSB35_12400) 2972267..2973727 - 1461 WP_004525423.1 metallophosphoesterase -
OSB35_RS12405 (OSB35_12405) 2973974..2974090 + 117 Protein_2470 IS3 family transposase -
OSB35_RS12410 (OSB35_12410) 2974317..2974709 - 393 Protein_2471 IS110 family transposase -
OSB35_RS12415 (OSB35_12415) 2974708..2975091 - 384 Protein_2472 integrase core domain-containing protein -
OSB35_RS12420 (OSB35_12420) 2975738..2976022 - 285 WP_004525420.1 BrnA antitoxin family protein Antitoxin
OSB35_RS12425 (OSB35_12425) 2976006..2976275 - 270 WP_004557717.1 BrnT family toxin Toxin
OSB35_RS12430 (OSB35_12430) 2976828..2977103 + 276 WP_004525419.1 hypothetical protein -
OSB35_RS12435 (OSB35_12435) 2977113..2977244 + 132 WP_009923452.1 bacteriophage protein Gp48 -
OSB35_RS12440 (OSB35_12440) 2977380..2977601 + 222 WP_004525418.1 hypothetical protein -
OSB35_RS12445 (OSB35_12445) 2977649..2977867 + 219 WP_004552392.1 hypothetical protein -
OSB35_RS12450 (OSB35_12450) 2978098..2978679 - 582 WP_004542548.1 hypothetical protein -
OSB35_RS12455 (OSB35_12455) 2978935..2979084 + 150 WP_004542626.1 bacteriophage protein Gp44 -
OSB35_RS12460 (OSB35_12460) 2979120..2979701 + 582 Protein_2481 SPFH domain-containing protein -
OSB35_RS12465 (OSB35_12465) 2979852..2980280 + 429 Protein_2482 integrase core domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2972267..2982591 10324


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-81)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(27-88)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10183.54 Da        Isoelectric Point: 5.6831

>T264875 WP_004557717.1 NZ_CP111138:c2976275-2976006 [Burkholderia pseudomallei]
MDITFDPTKNETNIAKHGVSLALAAQLDWSDVLSYVDDRRDYSEVREVGFGVIGDRLYCVVFTQRGDLMHIISMRKANKR
EVKSYVEQA

Download         Length: 270 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10697.10 Da        Isoelectric Point: 5.8930

>AT264875 WP_004525420.1 NZ_CP111138:c2976022-2975738 [Burkholderia pseudomallei]
MSSKRKIVMPTDEEDAAINRGIAADPDTFEVPAEDFAKMTRRGKRGRPPLEAPKVQLTVRYDVDIVDAFKATGEGWQTRM
NDALREWLREHQPA

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K9CXB8

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6L9S8

References