264874

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2272045..2273801 Replicon chromosome
Accession NZ_CP111138
Organism Burkholderia pseudomallei strain MSHR1713

Toxin (Protein)


Gene name doc Uniprot ID B1H5R2
Locus tag OSB35_RS09450 Protein ID WP_004524002.1
Coordinates 2272896..2273801 (-) Length 302 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q63LW2
Locus tag OSB35_RS09445 Protein ID WP_004195450.1
Coordinates 2272045..2272899 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSB35_RS09425 (OSB35_09425) 2267261..2268751 - 1491 WP_004524006.1 aldehyde dehydrogenase -
OSB35_RS09430 (OSB35_09430) 2268777..2269592 - 816 WP_004524005.1 aspartate dehydrogenase -
OSB35_RS09435 (OSB35_09435) 2269585..2271258 - 1674 WP_004524004.1 thiamine pyrophosphate-binding protein -
OSB35_RS09440 (OSB35_09440) 2271251..2272048 - 798 WP_004524003.1 SDR family oxidoreductase -
OSB35_RS09445 (OSB35_09445) 2272045..2272899 - 855 WP_004195450.1 IclR family transcriptional regulator Antitoxin
OSB35_RS09450 (OSB35_09450) 2272896..2273801 - 906 WP_004524002.1 alpha/beta fold hydrolase Toxin
OSB35_RS09455 (OSB35_09455) 2273818..2274345 - 528 WP_004524001.1 cupin domain-containing protein -
OSB35_RS09460 (OSB35_09460) 2274384..2275154 - 771 WP_004524000.1 SDR family oxidoreductase -
OSB35_RS09465 (OSB35_09465) 2275151..2276218 - 1068 WP_004523999.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
OSB35_RS09470 (OSB35_09470) 2276253..2276564 - 312 WP_004184841.1 hypothetical protein -
OSB35_RS09475 (OSB35_09475) 2276566..2276883 - 318 WP_004184916.1 non-heme iron oxygenase ferredoxin subunit -
OSB35_RS09480 (OSB35_09480) 2277318..2278406 + 1089 WP_004523998.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(54-284)

Antitoxin

Transcription regulator IclR, C-terminal

(143-265)


Sequences

Toxin        


Download         Length: 302 a.a.        Molecular weight: 30556.69 Da        Isoelectric Point: 8.4944

>T264874 WP_004524002.1 NZ_CP111138:c2273801-2272896 [Burkholderia pseudomallei]
MSTISTTTTEAGAAPFAALLARFPERRAAVGGAGVIGYREAGEAHARRAGCEPVVLLHGIGSGAASWVRQLDALGATRRA
LAWDAPGYGASSRVAADSPVAADYAASLAAWLDALRIERCVLVGHSLGAIMAGAFARIAGERLAGLLLISPAGGYGSAPA
DVRAGRRDSRLALLASLGPQGLAAERSANMLSAQASGAAREWVRWNMARIAPAGYAQATHLLANADLASDLAHCRGRIAV
AVGGDDAITPPAACERIARAAGVGLQVIARAGHAGYVEAPDAYSALIDAFCRQCDGSRGTP

Download         Length: 906 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31152.56 Da        Isoelectric Point: 6.8932

>AT264874 WP_004195450.1 NZ_CP111138:c2272899-2272045 [Burkholderia pseudomallei]
MSEPLLKDADDARNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTAHIVIRDGRDVVFVAKAQNAGNAFGSVRVNVGTRLPAHATTHGHV
LMGDLSLAQLRALYPERALERVTKATPETVDALFDVIRDDARRGYGIGNSAFERDISVVTAPVRNEASRIVAVVTVTVPR
PEIDAALVAEGLVEKVVRAAAELSRRLNYRSDDENTYLKALGLR

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A095K1W1

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4FRW8

References