Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 1496411..1498170 | Replicon | chromosome |
Accession | NZ_CP111138 | ||
Organism | Burkholderia pseudomallei strain MSHR1713 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | B1H781 |
Locus tag | OSB35_RS06435 | Protein ID | WP_004525276.1 |
Coordinates | 1496411..1497763 (-) | Length | 451 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | A0A0F6L1Y8 |
Locus tag | OSB35_RS06440 | Protein ID | WP_004525277.1 |
Coordinates | 1497760..1498170 (-) | Length | 137 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
OSB35_RS06415 (OSB35_06415) | 1492707..1493048 | - | 342 | WP_004525272.1 | hypothetical protein | - |
OSB35_RS06420 (OSB35_06420) | 1493322..1494275 | - | 954 | WP_004187785.1 | agmatinase | - |
OSB35_RS06425 (OSB35_06425) | 1494442..1495356 | + | 915 | WP_004525274.1 | LysR family transcriptional regulator | - |
OSB35_RS06430 (OSB35_06430) | 1495791..1496243 | + | 453 | WP_004198842.1 | hypothetical protein | - |
OSB35_RS06435 (OSB35_06435) | 1496411..1497763 | - | 1353 | WP_004525276.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
OSB35_RS06440 (OSB35_06440) | 1497760..1498170 | - | 411 | WP_004525277.1 | helix-turn-helix domain-containing protein | Antitoxin |
OSB35_RS06445 (OSB35_06445) | 1498508..1498771 | - | 264 | WP_004199789.1 | hypothetical protein | - |
OSB35_RS06450 (OSB35_06450) | 1499236..1501632 | + | 2397 | WP_052115519.1 | cellulose biosynthesis cyclic di-GMP-binding regulatory protein BcsB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 1490054..1499219 | 9165 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 451 a.a. Molecular weight: 49790.80 Da Isoelectric Point: 9.8300
>T264873 WP_004525276.1 NZ_CP111138:c1497763-1496411 [Burkholderia pseudomallei]
VSARRARATRLHLWMNGLPVGYWEHARDGERLVYFDEWIGDPQGRPLSLSLPFTPGNQPYRGRLVSDYFDNLLPDSEPIR
RRIAMRYRTGGTSAFALLATLGRDCVGALQMLPPDEAPDDIERIRGHALADADIARLLREVTSAPQAGRHAPLDDLRLSI
AGAQEKTALLRHRGRWLLPEGSTPTTHILKLPLGLVGNRRADMRTSVENEWLCARIVAAYGLPVARCDIAQFDDQKALVV
ERFDRRPSRDARWLLRLPQEDMCQATGTSALDKYQADGGPGIETIMEVLAGSEHARDDRRAFFAAQIVFWLLAATDGHAK
NFSIAHLPGNRYRSTPLYDVLSAHPVIGRGANQLPAQRARLAMGVRGKHIHYPLHQIRRRHWIAQGQRVGFAPADVDALI
DTLTARTAGVVDAVSARLPRDFPRDVADAIFSGMLGLSARLAGDAAARAP
VSARRARATRLHLWMNGLPVGYWEHARDGERLVYFDEWIGDPQGRPLSLSLPFTPGNQPYRGRLVSDYFDNLLPDSEPIR
RRIAMRYRTGGTSAFALLATLGRDCVGALQMLPPDEAPDDIERIRGHALADADIARLLREVTSAPQAGRHAPLDDLRLSI
AGAQEKTALLRHRGRWLLPEGSTPTTHILKLPLGLVGNRRADMRTSVENEWLCARIVAAYGLPVARCDIAQFDDQKALVV
ERFDRRPSRDARWLLRLPQEDMCQATGTSALDKYQADGGPGIETIMEVLAGSEHARDDRRAFFAAQIVFWLLAATDGHAK
NFSIAHLPGNRYRSTPLYDVLSAHPVIGRGANQLPAQRARLAMGVRGKHIHYPLHQIRRRHWIAQGQRVGFAPADVDALI
DTLTARTAGVVDAVSARLPRDFPRDVADAIFSGMLGLSARLAGDAAARAP
Download Length: 1353 bp
Antitoxin
Download Length: 137 a.a. Molecular weight: 14480.82 Da Isoelectric Point: 11.8540
>AT264873 WP_004525277.1 NZ_CP111138:c1498170-1497760 [Burkholderia pseudomallei]
MAILIEHEIKTLGQLRPILRGFRKSAGLTQAMLASRLGVTQQTYAQFEANPASASVERLFKVLRALDIELTLTLTQVYAA
PAGKDKGEVAKTAAGARARAGARRAAPPASAPAPSAAGRAPRPARKRAAPKKREDW
MAILIEHEIKTLGQLRPILRGFRKSAGLTQAMLASRLGVTQQTYAQFEANPASASVERLFKVLRALDIELTLTLTQVYAA
PAGKDKGEVAKTAAGARARAGARRAAPPASAPAPSAAGRAPRPARKRAAPKKREDW
Download Length: 411 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2K3EM91 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0F6L1Y8 |