264872

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT_toxin-BrnA
Location 1799450..1799987 Replicon chromosome
Accession NZ_CP111137
Organism Burkholderia pseudomallei strain MSHR7744

Toxin (Protein)


Gene name brnT Uniprot ID A0A2K9CXB8
Locus tag OSB53_RS25695 Protein ID WP_004557717.1
Coordinates 1799718..1799987 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID Q63NA3
Locus tag OSB53_RS25690 Protein ID WP_004525420.1
Coordinates 1799450..1799734 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSB53_RS25665 (OSB53_25665) 1794558..1795928 - 1371 WP_004525424.1 cytochrome c peroxidase -
OSB53_RS25670 (OSB53_25670) 1795979..1797439 - 1461 WP_004525423.1 metallophosphoesterase -
OSB53_RS25675 (OSB53_25675) 1797686..1797802 + 117 Protein_1449 IS3 family transposase -
OSB53_RS25680 (OSB53_25680) 1798029..1798421 - 393 Protein_1450 IS110 family transposase -
OSB53_RS25685 (OSB53_25685) 1798420..1798803 - 384 Protein_1451 integrase core domain-containing protein -
OSB53_RS25690 (OSB53_25690) 1799450..1799734 - 285 WP_004525420.1 BrnA antitoxin family protein Antitoxin
OSB53_RS25695 (OSB53_25695) 1799718..1799987 - 270 WP_004557717.1 BrnT family toxin Toxin
OSB53_RS25700 (OSB53_25700) 1800540..1800815 + 276 WP_004525419.1 hypothetical protein -
OSB53_RS25705 (OSB53_25705) 1800825..1800956 + 132 WP_009923452.1 bacteriophage protein Gp48 -
OSB53_RS25710 (OSB53_25710) 1801092..1801313 + 222 WP_004525418.1 hypothetical protein -
OSB53_RS25715 (OSB53_25715) 1801361..1801579 + 219 WP_004552392.1 hypothetical protein -
OSB53_RS25720 (OSB53_25720) 1801810..1802391 - 582 WP_004542548.1 hypothetical protein -
OSB53_RS25725 (OSB53_25725) 1802647..1802796 + 150 WP_004542626.1 bacteriophage protein Gp44 -
OSB53_RS25730 (OSB53_25730) 1802832..1803365 + 534 Protein_1460 SPFH domain-containing protein -
OSB53_RS25735 (OSB53_25735) 1803564..1803992 + 429 Protein_1461 integrase core domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1795979..1806303 10324


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-81)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(27-88)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10183.54 Da        Isoelectric Point: 5.6831

>T264872 WP_004557717.1 NZ_CP111137:c1799987-1799718 [Burkholderia pseudomallei]
MDITFDPTKNETNIAKHGVSLALAAQLDWSDVLSYVDDRRDYSEVREVGFGVIGDRLYCVVFTQRGDLMHIISMRKANKR
EVKSYVEQA

Download         Length: 270 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10697.10 Da        Isoelectric Point: 5.8930

>AT264872 WP_004525420.1 NZ_CP111137:c1799734-1799450 [Burkholderia pseudomallei]
MSSKRKIVMPTDEEDAAINRGIAADPDTFEVPAEDFAKMTRRGKRGRPPLEAPKVQLTVRYDVDIVDAFKATGEGWQTRM
NDALREWLREHQPA

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K9CXB8

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6L9S8

References