Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1095745..1097501 Replicon chromosome
Accession NZ_CP111137
Organism Burkholderia pseudomallei strain MSHR7744

Toxin (Protein)


Gene name doc Uniprot ID B1H5R2
Locus tag OSB53_RS22720 Protein ID WP_004524002.1
Coordinates 1096596..1097501 (-) Length 302 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q63LW2
Locus tag OSB53_RS22715 Protein ID WP_004195450.1
Coordinates 1095745..1096599 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSB53_RS22695 (OSB53_22695) 1090961..1092451 - 1491 WP_004524006.1 aldehyde dehydrogenase -
OSB53_RS22700 (OSB53_22700) 1092477..1093292 - 816 WP_004524005.1 aspartate dehydrogenase -
OSB53_RS22705 (OSB53_22705) 1093285..1094958 - 1674 WP_004524004.1 thiamine pyrophosphate-binding protein -
OSB53_RS22710 (OSB53_22710) 1094951..1095748 - 798 WP_004524003.1 SDR family oxidoreductase -
OSB53_RS22715 (OSB53_22715) 1095745..1096599 - 855 WP_004195450.1 IclR family transcriptional regulator Antitoxin
OSB53_RS22720 (OSB53_22720) 1096596..1097501 - 906 WP_004524002.1 alpha/beta fold hydrolase Toxin
OSB53_RS22725 (OSB53_22725) 1097518..1098045 - 528 WP_004524001.1 cupin domain-containing protein -
OSB53_RS22730 (OSB53_22730) 1098084..1098854 - 771 WP_004524000.1 SDR family oxidoreductase -
OSB53_RS22735 (OSB53_22735) 1098851..1099918 - 1068 WP_004523999.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
OSB53_RS22740 (OSB53_22740) 1099953..1100264 - 312 WP_004184841.1 hypothetical protein -
OSB53_RS22745 (OSB53_22745) 1100266..1100583 - 318 WP_004184916.1 non-heme iron oxygenase ferredoxin subunit -
OSB53_RS22750 (OSB53_22750) 1101018..1102106 + 1089 WP_004523998.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(54-284)

Antitoxin

Transcription regulator IclR, C-terminal

(143-265)


Sequences

Toxin        


Download         Length: 302 a.a.        Molecular weight: 30556.69 Da        Isoelectric Point: 8.4944

>T264871 WP_004524002.1 NZ_CP111137:c1097501-1096596 [Burkholderia pseudomallei]
MSTISTTTTEAGAAPFAALLARFPERRAAVGGAGVIGYREAGEAHARRAGCEPVVLLHGIGSGAASWVRQLDALGATRRA
LAWDAPGYGASSRVAADSPVAADYAASLAAWLDALRIERCVLVGHSLGAIMAGAFARIAGERLAGLLLISPAGGYGSAPA
DVRAGRRDSRLALLASLGPQGLAAERSANMLSAQASGAAREWVRWNMARIAPAGYAQATHLLANADLASDLAHCRGRIAV
AVGGDDAITPPAACERIARAAGVGLQVIARAGHAGYVEAPDAYSALIDAFCRQCDGSRGTP

Download         Length: 906 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31152.56 Da        Isoelectric Point: 6.8932

>AT264871 WP_004195450.1 NZ_CP111137:c1096599-1095745 [Burkholderia pseudomallei]
MSEPLLKDADDARNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTAHIVIRDGRDVVFVAKAQNAGNAFGSVRVNVGTRLPAHATTHGHV
LMGDLSLAQLRALYPERALERVTKATPETVDALFDVIRDDARRGYGIGNSAFERDISVVTAPVRNEASRIVAVVTVTVPR
PEIDAALVAEGLVEKVVRAAAELSRRLNYRSDDENTYLKALGLR

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A095K1W1

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4FRW8

References