Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 359857..361616 Replicon chromosome
Accession NZ_CP111137
Organism Burkholderia pseudomallei strain MSHR7744

Toxin (Protein)


Gene name hipA Uniprot ID B1H781
Locus tag OSB53_RS19895 Protein ID WP_004525276.1
Coordinates 359857..361209 (-) Length 451 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0F6L1Y8
Locus tag OSB53_RS19900 Protein ID WP_004525277.1
Coordinates 361206..361616 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSB53_RS19875 (OSB53_19875) 356153..356494 - 342 WP_004525272.1 hypothetical protein -
OSB53_RS19880 (OSB53_19880) 356768..357721 - 954 WP_004187785.1 agmatinase -
OSB53_RS19885 (OSB53_19885) 357888..358802 + 915 WP_004525274.1 LysR family transcriptional regulator -
OSB53_RS19890 (OSB53_19890) 359237..359689 + 453 WP_004198842.1 hypothetical protein -
OSB53_RS19895 (OSB53_19895) 359857..361209 - 1353 WP_004525276.1 type II toxin-antitoxin system HipA family toxin Toxin
OSB53_RS19900 (OSB53_19900) 361206..361616 - 411 WP_004525277.1 helix-turn-helix domain-containing protein Antitoxin
OSB53_RS19905 (OSB53_19905) 361954..362217 - 264 WP_004199789.1 hypothetical protein -
OSB53_RS19910 (OSB53_19910) 362682..365078 + 2397 WP_052115519.1 cellulose biosynthesis cyclic di-GMP-binding regulatory protein BcsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 353500..362665 9165


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(158-406)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-71)


Sequences

Toxin        


Download         Length: 451 a.a.        Molecular weight: 49790.80 Da        Isoelectric Point: 9.8300

>T264870 WP_004525276.1 NZ_CP111137:c361209-359857 [Burkholderia pseudomallei]
VSARRARATRLHLWMNGLPVGYWEHARDGERLVYFDEWIGDPQGRPLSLSLPFTPGNQPYRGRLVSDYFDNLLPDSEPIR
RRIAMRYRTGGTSAFALLATLGRDCVGALQMLPPDEAPDDIERIRGHALADADIARLLREVTSAPQAGRHAPLDDLRLSI
AGAQEKTALLRHRGRWLLPEGSTPTTHILKLPLGLVGNRRADMRTSVENEWLCARIVAAYGLPVARCDIAQFDDQKALVV
ERFDRRPSRDARWLLRLPQEDMCQATGTSALDKYQADGGPGIETIMEVLAGSEHARDDRRAFFAAQIVFWLLAATDGHAK
NFSIAHLPGNRYRSTPLYDVLSAHPVIGRGANQLPAQRARLAMGVRGKHIHYPLHQIRRRHWIAQGQRVGFAPADVDALI
DTLTARTAGVVDAVSARLPRDFPRDVADAIFSGMLGLSARLAGDAAARAP

Download         Length: 1353 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14480.82 Da        Isoelectric Point: 11.8540

>AT264870 WP_004525277.1 NZ_CP111137:c361616-361206 [Burkholderia pseudomallei]
MAILIEHEIKTLGQLRPILRGFRKSAGLTQAMLASRLGVTQQTYAQFEANPASASVERLFKVLRALDIELTLTLTQVYAA
PAGKDKGEVAKTAAGARARAGARRAAPPASAPAPSAAGRAPRPARKRAAPKKREDW

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K3EM91

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6L1Y8

References