Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4871555..4872131 Replicon chromosome
Accession NZ_CP111115
Organism Raoultella sp. DY2415

Toxin (Protein)


Gene name shpA Uniprot ID A0A808YBH6
Locus tag OQV00_RS23125 Protein ID WP_032716505.1
Coordinates 4871844..4872131 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID -
Locus tag OQV00_RS23120 Protein ID WP_064357555.1
Coordinates 4871555..4871857 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQV00_RS23105 4867494..4867829 + 336 WP_100663658.1 endoribonuclease SymE -
OQV00_RS23110 4868060..4870132 + 2073 WP_100663657.1 AAA family ATPase -
OQV00_RS23115 4870132..4871454 + 1323 WP_069476271.1 restriction endonuclease -
OQV00_RS23120 4871555..4871857 - 303 WP_064357555.1 BrnA antitoxin family protein Antitoxin
OQV00_RS23125 4871844..4872131 - 288 WP_032716505.1 BrnT family toxin Toxin
OQV00_RS23130 4872248..4872667 - 420 WP_004857515.1 FosA family fosfomycin resistance glutathione transferase -
OQV00_RS23135 4872661..4873569 - 909 WP_004857513.1 LysR family transcriptional regulator -
OQV00_RS23140 4873657..4874439 + 783 WP_048024655.1 NAD(P)H-dependent oxidoreductase -
OQV00_RS23145 4874587..4875165 + 579 WP_004857495.1 TetR/AcrR family transcriptional regulator -
OQV00_RS23150 4875309..4876121 + 813 WP_004857492.1 winged helix-turn-helix domain-containing protein -
OQV00_RS23155 4876118..4876636 + 519 WP_015585229.1 FidL-like protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(35-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11131.57 Da        Isoelectric Point: 7.5235

>T264867 WP_032716505.1 NZ_CP111115:c4872131-4871844 [Raoultella sp. DY2415]
MPMEFEWDANKAASNLRKHGIRFEEAVLVFDDPQHLSRHDRYENGEYRWQTIGLVHGVIVVLVAHSIRFESGTEVIRIIS
ARKADKKERSRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11509.97 Da        Isoelectric Point: 7.0165

>AT264867 WP_064357555.1 NZ_CP111115:c4871857-4871555 [Raoultella sp. DY2415]
MSMVKHKRDNPTALTAQREDELKALAKKSDDDIDYSDIPSSDDEPWSEAVRGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMNRDLGEK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808YBH6

Antitoxin

Source ID Structure

References