Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2768017..2769620 Replicon chromosome
Accession NZ_CP111115
Organism Raoultella sp. DY2415

Toxin (Protein)


Gene name hipA Uniprot ID A0A1Y6GHD8
Locus tag OQV00_RS13115 Protein ID WP_015584335.1
Coordinates 2768017..2769348 (-) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A808YAX5
Locus tag OQV00_RS13120 Protein ID WP_032717448.1
Coordinates 2769348..2769620 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OQV00_RS13100 2763891..2764805 - 915 WP_015584333.1 branched-chain amino acid ABC transporter permease -
OQV00_RS13105 2764905..2765963 - 1059 WP_162180097.1 branched-chain amino acid ABC transporter substrate-binding protein -
OQV00_RS13110 2766678..2768084 + 1407 WP_015584334.1 glycoside hydrolase family 10 protein -
OQV00_RS13115 2768017..2769348 - 1332 WP_015584335.1 type II toxin-antitoxin system HipA family toxin Toxin
OQV00_RS13120 2769348..2769620 - 273 WP_032717448.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OQV00_RS13125 2769824..2770378 - 555 WP_266280582.1 RNA polymerase sigma factor -
OQV00_RS13130 2770384..2770809 - 426 WP_032724724.1 hypothetical protein -
OQV00_RS13135 2770943..2771896 - 954 WP_004861921.1 hypothetical protein -
OQV00_RS13140 2772110..2772742 - 633 WP_266280585.1 class I SAM-dependent methyltransferase -
OQV00_RS13145 2772762..2774003 - 1242 WP_004861912.1 sensor domain-containing diguanylate cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 49327.66 Da        Isoelectric Point: 6.7012

>T264865 WP_015584335.1 NZ_CP111115:c2769348-2768017 [Raoultella sp. DY2415]
MATLVTWMNNERVGELIKQANGAHLFRYEEAWMRNPRARPLSLSLPLQYGNITDEAVFNYFDNLLPDSPRVRDRIVKRYQ
ARSKQPFDLLAEIGRDSVGAVTLLPPGENAPRGALSWEPLDNHALDALLTAYQSDIPLGMVNEHDDFRISVAGAQEKTAL
LKIGEQWCIPTGTTPTTHIIKLPIGEIKQPDAVLDLSESVDNEYLCLALARALGFAVPPASIIQTASIRALAVERFDRRW
AQEKTVLLRLPQEDLCQAFGIPSSIKYESDGGPGIRAIMAFLVGSSEALEDRYNFMKFMVFQWLIGATDGHAKNFSIFLQ
PGGSYRLTPFYDIISAFPLLGGKGLHLSDLKLSMSLKASKGRKTEIQTLYPRHFLATAKEVGFAQQQMLEILRYFVDNVP
RAVEAVKGTLPPDFSQPVYEAITDRLLWVHSRLQNAMAASPSG

Download         Length: 1332 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10365.71 Da        Isoelectric Point: 5.7971

>AT264865 WP_032717448.1 NZ_CP111115:c2769620-2769348 [Raoultella sp. DY2415]
MSPSPTIYSPVQLANYLKLVRQKNQWTQSELAQRMGIKQATVSNFENHPEKTTLTTVFKILQSLELSMAICEKNAPDTDD
NRDNPRDLEW

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Y6GHD8

Antitoxin

Source ID Structure
AlphaFold DB A0A808YAX5

References