Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1838878..1839494 Replicon chromosome
Accession NZ_CP111114
Organism Pseudomonas koreensis strain FP1691

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag OPS05_RS08270 Protein ID WP_134785765.1
Coordinates 1838878..1839090 (+) Length 71 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID W6W5D4
Locus tag OPS05_RS08275 Protein ID WP_007961664.1
Coordinates 1839090..1839494 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OPS05_RS08245 (OPS05_08245) 1834982..1835518 + 537 WP_041072930.1 DsbE family thiol:disulfide interchange protein -
OPS05_RS08250 (OPS05_08250) 1835515..1835985 + 471 WP_003222948.1 cytochrome c-type biogenesis protein CcmH -
OPS05_RS08255 (OPS05_08255) 1835982..1837184 + 1203 WP_134785763.1 c-type cytochrome biogenesis protein CcmI -
OPS05_RS08260 (OPS05_08260) 1837212..1837616 + 405 WP_134785764.1 hypothetical protein -
OPS05_RS08265 (OPS05_08265) 1837723..1838610 - 888 WP_266276287.1 LysR family transcriptional regulator -
OPS05_RS08270 (OPS05_08270) 1838878..1839090 + 213 WP_134785765.1 type II toxin-antitoxin system HicA family toxin Toxin
OPS05_RS08275 (OPS05_08275) 1839090..1839494 + 405 WP_007961664.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OPS05_RS08280 (OPS05_08280) 1839553..1840740 - 1188 WP_096796242.1 MFS transporter -
OPS05_RS08285 (OPS05_08285) 1840984..1841604 + 621 WP_134785766.1 DUF5666 domain-containing protein -
OPS05_RS08290 (OPS05_08290) 1841884..1843161 + 1278 WP_134785767.1 hypothetical protein -
OPS05_RS08295 (OPS05_08295) 1843148..1844095 + 948 WP_127646222.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 8025.26 Da        Isoelectric Point: 10.3701

>T264853 WP_134785765.1 NZ_CP111114:1838878-1839090 [Pseudomonas koreensis]
VQSRLLIKELEEAGWTLDRVIGSHHIFTHRYNPYTIPVPHPKKDLPLGTVKSIRRRAGLYHPPASYKGDP

Download         Length: 213 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14836.80 Da        Isoelectric Point: 4.2870

>AT264853 WP_007961664.1 NZ_CP111114:1839090-1839494 [Pseudomonas koreensis]
MQYPICIEWGDDNTAIGIQIPDIPGAVTAGDTFEDAYNAAVEVAHLMLQEMAADGESIPMPTSAAAHRNNPEFADMGWGM
LELDISPYMGKTEKVNVTLPGYVIQRIDRYVREHNVKSRSSFLADAAMEKLVRY

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W6W5D4

References