Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 848088..848617 Replicon chromosome
Accession NZ_CP111111
Organism Staphylococcus epidermidis strain KCTC 13172

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag ORT68_RS03950 Protein ID WP_001829891.1
Coordinates 848255..848617 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag ORT68_RS03945 Protein ID WP_001829931.1
Coordinates 848088..848258 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORT68_RS03920 (ORT68_03920) 843912..844391 + 480 WP_010959254.1 PH domain-containing protein -
ORT68_RS03925 (ORT68_03925) 844384..845889 + 1506 WP_002457110.1 PH domain-containing protein -
ORT68_RS03930 (ORT68_03930) 845876..846385 + 510 WP_002457109.1 PH domain-containing protein -
ORT68_RS03935 (ORT68_03935) 846433..846786 + 354 WP_002457108.1 holo-ACP synthase -
ORT68_RS03940 (ORT68_03940) 846853..848001 + 1149 WP_002457107.1 alanine racemase -
ORT68_RS03945 (ORT68_03945) 848088..848258 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
ORT68_RS03950 (ORT68_03950) 848255..848617 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
ORT68_RS03955 (ORT68_03955) 848962..849963 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
ORT68_RS03960 (ORT68_03960) 850063..850389 + 327 WP_001829952.1 anti-sigma factor antagonist -
ORT68_RS03965 (ORT68_03965) 850391..850870 + 480 WP_001829903.1 anti-sigma B factor RsbW -
ORT68_RS03970 (ORT68_03970) 850845..851615 + 771 WP_002440602.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T264848 WP_001829891.1 NZ_CP111111:848255-848617 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT264848 WP_001829931.1 NZ_CP111111:848088-848258 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References