Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 836903..837412 Replicon chromosome
Accession NZ_CP111111
Organism Staphylococcus epidermidis strain KCTC 13172

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag ORT68_RS03890 Protein ID WP_001829980.1
Coordinates 837203..837412 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag ORT68_RS03885 Protein ID WP_001829893.1
Coordinates 836903..837196 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ORT68_RS03860 (ORT68_03860) 831911..832699 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
ORT68_RS03865 (ORT68_03865) 832705..833343 + 639 WP_002505076.1 thiamine phosphate synthase -
ORT68_RS03870 (ORT68_03870) 833432..834304 + 873 WP_002458703.1 membrane protein insertase YidC -
ORT68_RS03875 (ORT68_03875) 834410..835063 - 654 WP_001829983.1 HD domain-containing protein -
ORT68_RS03880 (ORT68_03880) 835245..836729 - 1485 WP_002457116.1 cardiolipin synthase -
ORT68_RS03885 (ORT68_03885) 836903..837196 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
ORT68_RS03890 (ORT68_03890) 837203..837412 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
ORT68_RS03895 (ORT68_03895) 837555..837692 + 138 WP_001829949.1 Lmo0850 family protein -
ORT68_RS03900 (ORT68_03900) 837791..839002 - 1212 WP_002486299.1 FtsW/RodA/SpoVE family cell cycle protein -
ORT68_RS03905 (ORT68_03905) 839393..840466 + 1074 WP_001832735.1 D-alanine--D-alanine ligase -
ORT68_RS03910 (ORT68_03910) 840478..841833 + 1356 WP_002457113.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T264847 WP_001829980.1 NZ_CP111111:837203-837412 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT264847 WP_001829893.1 NZ_CP111111:836903-837196 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References