Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2600867..2602462 Replicon chromosome
Accession NZ_CP111110
Organism Pseudomonas chengduensis strain BC1815

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OF113_RS12210 Protein ID WP_266208477.1
Coordinates 2601137..2602462 (-) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A1G5YAZ4
Locus tag OF113_RS12205 Protein ID WP_017676963.1
Coordinates 2600867..2601136 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OF113_RS12190 (OF113_12190) 2596760..2597824 + 1065 WP_059392109.1 type VI secretion system protein TssA -
OF113_RS12195 (OF113_12195) 2598077..2598832 - 756 WP_212739816.1 IS21-like element helper ATPase IstB -
OF113_RS12200 (OF113_12200) 2598850..2600364 - 1515 WP_266208476.1 IS21 family transposase -
OF113_RS12205 (OF113_12205) 2600867..2601136 - 270 WP_017676963.1 helix-turn-helix domain-containing protein Antitoxin
OF113_RS12210 (OF113_12210) 2601137..2602462 - 1326 WP_266208477.1 HipA domain-containing protein Toxin
OF113_RS12215 (OF113_12215) 2602715..2602921 + 207 WP_017676961.1 hypothetical protein -
OF113_RS12220 (OF113_12220) 2603030..2604172 + 1143 WP_266208478.1 elongation factor P maturation arginine rhamnosyltransferase EarP -
OF113_RS12225 (OF113_12225) 2604207..2604779 + 573 WP_003460252.1 elongation factor P -
OF113_RS12230 (OF113_12230) 2604879..2605841 - 963 WP_039964599.1 LysR family transcriptional regulator -
OF113_RS12235 (OF113_12235) 2605942..2606709 + 768 WP_017676957.1 sulfite exporter TauE/SafE family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2580853..2602462 21609


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-382)

Antitoxin

Cro/C1-type helix-turn-helix domain

(25-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 49082.52 Da        Isoelectric Point: 6.0507

>T264843 WP_266208477.1 NZ_CP111110:c2602462-2601137 [Pseudomonas chengduensis]
MHSLTLQLYSGHAWHDAMHLNFEQPEAGLAGACSFGYGQAYLLETLEHIGSRLEHAVSVTVPLDWESYRASEAPAFLHDI
LPAGAARRFLLQRLGDQKPENLGLDLFLLSRCAPAPVGNLRIKEAAAALQESPLLGFSREDVINRDARFLEYAYERGAAI
GGATGAGGEAPKLLLTEDREGALHPDAALPDESATRHWFVKFARNQARQTDQDILRSEFCYYRAIQRLGLDTVPAEGLAL
EEGRKPSLWMHRFDRHLSAAGVERSAMESLYSLAGVTVPGSYLLHTDVLHHLVRLWQKTGQGAQVGDMIFEYLQRDLLNQ
ILGNSDNHGRNTSILRNSTGLKLAPIYDLAPMVMDDEGVTRTTKWPQSIEIAGEVNWRQACAALAQWTDADVLYERLRGA
AQDFLALPDLLSDQGLPNSTMNHPRIALRTLHQRLNRWELV

Download         Length: 1326 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10104.75 Da        Isoelectric Point: 10.7429

>AT264843 WP_017676963.1 NZ_CP111110:c2601136-2600867 [Pseudomonas chengduensis]
MDIIERNRILTEIQTQLASGELTIGQAVRKLRKEITGLQQARFAQMCKLSLRALRQLEHDESNPTVQTLNSVFNPFGMQV
GIVPKSRIQ

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1G5YAZ4

References