264837

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 205178..205871 Replicon plasmid pPALA50
Accession NZ_CP111035
Organism Pseudomonas aeruginosa strain PALA50

Toxin (Protein)


Gene name tad Uniprot ID N2IHR9
Locus tag PALA50_RS31090 Protein ID WP_003151133.1
Coordinates 205494..205871 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID N2IIN5
Locus tag PALA50_RS31085 Protein ID WP_001172026.1
Coordinates 205178..205513 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA50_RS31045 (PALA50_06134) 200920..201489 + 570 WP_023121486.1 LemA family protein -
PALA50_RS31050 (PALA50_06135) 201571..202038 + 468 WP_042853536.1 hypothetical protein -
PALA50_RS31055 (PALA50_06136) 202207..203181 + 975 WP_042853537.1 SGNH/GDSL hydrolase family protein -
PALA50_RS31060 (PALA50_06137) 203205..203885 - 681 WP_049267373.1 hypothetical protein -
PALA50_RS31065 203882..204007 - 126 WP_256675080.1 hypothetical protein -
PALA50_RS31070 (PALA50_06138) 204110..204481 - 372 WP_023103794.1 hypothetical protein -
PALA50_RS31075 (PALA50_06139) 204478..204804 - 327 WP_000091614.1 hypothetical protein -
PALA50_RS31080 (PALA50_06140) 204828..205163 - 336 WP_000741275.1 hypothetical protein -
PALA50_RS31085 (PALA50_06141) 205178..205513 - 336 WP_001172026.1 helix-turn-helix transcriptional regulator Antitoxin
PALA50_RS31090 (PALA50_06142) 205494..205871 - 378 WP_003151133.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA50_RS31095 (PALA50_06143) 206063..206665 + 603 WP_010465829.1 recombinase family protein -
PALA50_RS31100 (PALA50_06144) 206649..209678 + 3030 WP_010799689.1 Tn3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..222021 222021


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-93)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13705.78 Da        Isoelectric Point: 9.4693

>T264837 WP_003151133.1 NZ_CP111035:c205871-205494 [Pseudomonas aeruginosa]
MTNKEKPLEWIASSHKDLMALPSDVRRRFGYALSLAQIGDQDDAAKVLKGFGGAGVLEVVEDDAGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKADMDIIRARLKVAEVLAQELRNAKTNH

Download         Length: 378 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12201.39 Da        Isoelectric Point: 10.6058

>AT264837 WP_001172026.1 NZ_CP111035:c205513-205178 [Pseudomonas aeruginosa]
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A024ELN5

Antitoxin

Source ID Structure
AlphaFold DB A0A024EKI7

References