Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 194817..195456 Replicon plasmid pPALA50
Accession NZ_CP111035
Organism Pseudomonas aeruginosa strain PALA50

Toxin (Protein)


Gene name tad Uniprot ID Q4W1R0
Locus tag PALA50_RS31000 Protein ID WP_011270175.1
Coordinates 194817..195140 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID N2IIN5
Locus tag PALA50_RS31005 Protein ID WP_001172026.1
Coordinates 195121..195456 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA50_RS30965 (PALA50_06119) 190216..190650 + 435 WP_063839983.1 hypothetical protein -
PALA50_RS30970 (PALA50_06120) 190694..191107 - 414 WP_023121403.1 hypothetical protein -
PALA50_RS30975 (PALA50_06121) 191107..192276 - 1170 WP_023121402.1 ParB N-terminal domain-containing protein -
PALA50_RS30980 (PALA50_06122) 192273..193268 - 996 WP_023121401.1 ParA family protein -
PALA50_RS30985 193431..193853 + 423 WP_023121400.1 hypothetical protein -
PALA50_RS30990 193879..194292 + 414 WP_042853487.1 hypothetical protein -
PALA50_RS30995 (PALA50_06124) 194289..194753 + 465 WP_042853485.1 RES family NAD+ phosphorylase -
PALA50_RS31000 (PALA50_06125) 194817..195140 + 324 WP_011270175.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA50_RS31005 (PALA50_06126) 195121..195456 + 336 WP_001172026.1 helix-turn-helix transcriptional regulator Antitoxin
PALA50_RS31010 (PALA50_06127) 195471..195806 + 336 WP_000741275.1 hypothetical protein -
PALA50_RS31015 (PALA50_06128) 195830..196156 + 327 WP_000091614.1 hypothetical protein -
PALA50_RS31020 (PALA50_06129) 196153..196524 + 372 WP_023103794.1 hypothetical protein -
PALA50_RS31025 (PALA50_06130) 196555..196737 - 183 WP_269974169.1 hypothetical protein -
PALA50_RS31030 (PALA50_06131) 196753..198786 - 2034 WP_124124906.1 hypothetical protein -
PALA50_RS31035 (PALA50_06132) 198898..199467 + 570 WP_023121215.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..222021 222021


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(2-91)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-93)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11596.35 Da        Isoelectric Point: 9.5275

>T264836 WP_011270175.1 NZ_CP111035:194817-195140 [Pseudomonas aeruginosa]
MALPSDVRRRFGYALSLAQIGDQDDAAKVLKGFGGAGVLEVVEDDAGGTYRAVYTVKFAEAVFVLHCFQKKSKSGIATPK
ADMDIIRARLKVAEVLAQELRNAKTNH

Download         Length: 324 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12201.39 Da        Isoelectric Point: 10.6058

>AT264836 WP_001172026.1 NZ_CP111035:195121-195456 [Pseudomonas aeruginosa]
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q4W1R0

Antitoxin

Source ID Structure
AlphaFold DB A0A024EKI7

References