264834

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4530725..4531983 Replicon chromosome
Accession NZ_CP111034
Organism Pseudomonas aeruginosa strain PALA50

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag PALA50_RS20940 Protein ID WP_023084953.1
Coordinates 4530725..4531480 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PALA50_RS20945 Protein ID WP_003086329.1
Coordinates 4531615..4531983 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA50_RS20930 (PALA50_04161) 4525898..4528441 + 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -
PALA50_RS20935 (PALA50_04162) 4528596..4529957 - 1362 WP_003081943.1 DNA recombination protein RmuC -
PALA50_RS20940 (PALA50_04163) 4530725..4531480 - 756 WP_023084953.1 RES family NAD+ phosphorylase Toxin
PALA50_RS20945 (PALA50_04164) 4531615..4531983 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PALA50_RS20950 (PALA50_04165) 4532056..4533342 - 1287 WP_003163134.1 FAD-binding oxidoreductase -
PALA50_RS20955 (PALA50_04166) 4533398..4534987 - 1590 WP_003123191.1 aldehyde dehydrogenase family protein -
PALA50_RS20960 (PALA50_04167) 4535066..4535542 + 477 WP_023122241.1 hypothetical protein -
PALA50_RS20965 4535545..4535820 - 276 WP_171945305.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28310.49 Da        Isoelectric Point: 7.7294

>T264834 WP_023084953.1 NZ_CP111034:c4531480-4530725 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGMRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT264834 WP_003086329.1 NZ_CP111034:c4531983-4531615 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References