Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/- |
Location | 3571459..3572680 | Replicon | chromosome |
Accession | NZ_CP111034 | ||
Organism | Pseudomonas aeruginosa strain PALA50 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | A0A0C7CS07 |
Locus tag | PALA50_RS16405 | Protein ID | WP_003102740.1 |
Coordinates | 3572102..3572680 (+) | Length | 193 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | - |
Locus tag | PALA50_RS16400 | Protein ID | WP_003088112.1 |
Coordinates | 3571459..3572013 (+) | Length | 185 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
PALA50_RS16375 (PALA50_03254) | 3567027..3567578 | + | 552 | WP_003102727.1 | XRE family transcriptional regulator | - |
PALA50_RS16380 (PALA50_03255) | 3567575..3567973 | - | 399 | WP_003088123.1 | NADH-quinone oxidoreductase subunit A | - |
PALA50_RS16385 (PALA50_03256) | 3567986..3568309 | - | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
PALA50_RS16390 (PALA50_03257) | 3568640..3569101 | + | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
PALA50_RS16395 (PALA50_03258) | 3569106..3571301 | + | 2196 | WP_014603034.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
PALA50_RS16400 (PALA50_03259) | 3571459..3572013 | + | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
PALA50_RS16405 (PALA50_03260) | 3572102..3572680 | + | 579 | WP_003102740.1 | HD domain-containing protein | Toxin |
PALA50_RS16410 (PALA50_03261) | 3572789..3573976 | - | 1188 | WP_003102741.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
PALA50_RS16415 (PALA50_03262) | 3573966..3576137 | - | 2172 | WP_014603035.1 | type I secretion system permease/ATPase | - |
PALA50_RS16420 (PALA50_03263) | 3576127..3577404 | - | 1278 | WP_003102743.1 | TolC family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21869.70 Da Isoelectric Point: 5.3655
>T264833 WP_003102740.1 NZ_CP111034:3572102-3572680 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT264833 WP_003088112.1 NZ_CP111034:3571459-3572013 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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