264833

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/-
Location 3571459..3572680 Replicon chromosome
Accession NZ_CP111034
Organism Pseudomonas aeruginosa strain PALA50

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag PALA50_RS16405 Protein ID WP_003102740.1
Coordinates 3572102..3572680 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PALA50_RS16400 Protein ID WP_003088112.1
Coordinates 3571459..3572013 (+) Length 185 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA50_RS16375 (PALA50_03254) 3567027..3567578 + 552 WP_003102727.1 XRE family transcriptional regulator -
PALA50_RS16380 (PALA50_03255) 3567575..3567973 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
PALA50_RS16385 (PALA50_03256) 3567986..3568309 - 324 WP_003102734.1 multidrug efflux SMR transporter -
PALA50_RS16390 (PALA50_03257) 3568640..3569101 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
PALA50_RS16395 (PALA50_03258) 3569106..3571301 + 2196 WP_014603034.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PALA50_RS16400 (PALA50_03259) 3571459..3572013 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
PALA50_RS16405 (PALA50_03260) 3572102..3572680 + 579 WP_003102740.1 HD domain-containing protein Toxin
PALA50_RS16410 (PALA50_03261) 3572789..3573976 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
PALA50_RS16415 (PALA50_03262) 3573966..3576137 - 2172 WP_014603035.1 type I secretion system permease/ATPase -
PALA50_RS16420 (PALA50_03263) 3576127..3577404 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(16-170)

Antitoxin

(14-62)


Sequences


Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T264833 WP_003102740.1 NZ_CP111034:3572102-3572680 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp


Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT264833 WP_003088112.1 NZ_CP111034:3571459-3572013 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07


Antitoxin

Source ID Structure

References