Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 141692..142197 Replicon chromosome
Accession NZ_CP111034
Organism Pseudomonas aeruginosa strain PALA50

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag PALA50_RS00645 Protein ID WP_003121619.1
Coordinates 141692..141973 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag PALA50_RS00650 Protein ID WP_003112628.1
Coordinates 141970..142197 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA50_RS00620 (PALA50_00122) 136943..138292 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
PALA50_RS00625 (PALA50_00123) 138341..139027 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
PALA50_RS00630 (PALA50_00124) 139128..139862 + 735 WP_003117208.1 GntR family transcriptional regulator -
PALA50_RS00635 (PALA50_00125) 140042..140452 + 411 WP_003101225.1 aegerolysin family protein -
PALA50_RS00640 (PALA50_00126) 140484..141392 - 909 WP_016561475.1 LysR family transcriptional regulator -
PALA50_RS00645 (PALA50_00127) 141692..141973 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
PALA50_RS00650 (PALA50_00128) 141970..142197 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
PALA50_RS00655 (PALA50_00129) 142373..142993 - 621 WP_003101226.1 hypothetical protein -
PALA50_RS00660 (PALA50_00130) 143094..143594 + 501 WP_023121840.1 LEA type 2 family protein -
PALA50_RS00665 (PALA50_00131) 143667..144008 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
PALA50_RS00670 (PALA50_00132) 144090..145517 - 1428 WP_003083784.1 GABA permease -
PALA50_RS00675 (PALA50_00133) 145686..147179 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T264831 WP_003121619.1 NZ_CP111034:c141973-141692 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT264831 WP_003112628.1 NZ_CP111034:c142197-141970 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References