264828

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 5198491..5199099 Replicon chromosome
Accession NZ_CP111032
Organism Pseudomonas aeruginosa strain PALA54

Toxin (Protein)


Gene name PfiT Uniprot ID A0A444LUU5
Locus tag PALA54_RS24395 Protein ID WP_019486378.1
Coordinates 5198491..5198838 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag PALA54_RS24400 Protein ID WP_003114155.1
Coordinates 5198848..5199099 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA54_RS24375 (PALA54_04824) 5194424..5194921 + 498 WP_116850177.1 heat resistance protein PsiE-GI -
PALA54_RS24380 (PALA54_04825) 5194899..5195864 + 966 WP_112778053.1 zinc metalloprotease HtpX -
PALA54_RS24385 (PALA54_04826) 5195889..5197040 + 1152 WP_004265443.1 trypsin-like peptidase domain-containing protein -
PALA54_RS24390 (PALA54_04827) 5197273..5198181 + 909 WP_003141085.1 LysR family transcriptional regulator -
PALA54_RS24395 (PALA54_04828) 5198491..5198838 - 348 WP_019486378.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA54_RS24400 5198848..5199099 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PALA54_RS24405 (PALA54_04829) 5199313..5200296 - 984 WP_003114154.1 tyrosine-type recombinase/integrase -
PALA54_RS24410 (PALA54_04830) 5200296..5201588 - 1293 WP_003115206.1 hypothetical protein -
PALA54_RS24415 (PALA54_04832) 5201818..5203101 - 1284 WP_023124144.1 zonular occludens toxin family protein -
PALA54_RS24420 (PALA54_04833) 5203105..5203461 - 357 WP_003114150.1 DUF2523 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5116622..5210346 93724


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12956.72 Da        Isoelectric Point: 4.4212

>T264828 WP_019486378.1 NZ_CP111032:c5198838-5198491 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT264828 WP_003114155.1 NZ_CP111032:c5199099-5198848 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A444LUU5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References