Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4732587..4733846 Replicon chromosome
Accession NZ_CP111032
Organism Pseudomonas aeruginosa strain PALA54

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag PALA54_RS22045 Protein ID WP_031686398.1
Coordinates 4732587..4733342 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PALA54_RS22050 Protein ID WP_003086329.1
Coordinates 4733478..4733846 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA54_RS22035 (PALA54_04363) 4727758..4730301 + 2544 WP_031686396.1 acyl-homoserine-lactone acylase QuiP -
PALA54_RS22040 (PALA54_04364) 4730456..4731817 - 1362 WP_073647918.1 DNA recombination protein RmuC -
PALA54_RS22045 (PALA54_04365) 4732587..4733342 - 756 WP_031686398.1 RES family NAD+ phosphorylase Toxin
PALA54_RS22050 (PALA54_04366) 4733478..4733846 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PALA54_RS22055 (PALA54_04367) 4733919..4735205 - 1287 WP_003086327.1 FAD-binding oxidoreductase -
PALA54_RS22060 (PALA54_04368) 4735261..4736850 - 1590 WP_003123191.1 aldehyde dehydrogenase family protein -
PALA54_RS22065 (PALA54_04369) 4736929..4737405 + 477 WP_031686399.1 elongation factor GreAB -
PALA54_RS22070 (PALA54_04370) 4737408..4737683 - 276 WP_023088486.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28296.42 Da        Isoelectric Point: 7.7297

>T264826 WP_031686398.1 NZ_CP111032:c4733342-4732587 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALRLETAMAESAYYRCVLWSGMAMPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT264826 WP_003086329.1 NZ_CP111032:c4733846-4733478 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References