Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 3723030..3724251 | Replicon | chromosome |
| Accession | NZ_CP111032 | ||
| Organism | Pseudomonas aeruginosa strain PALA54 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | PALA54_RS17290 | Protein ID | WP_003118970.1 |
| Coordinates | 3723673..3724251 (+) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | PALA54_RS17285 | Protein ID | WP_003088112.1 |
| Coordinates | 3723030..3723584 (+) | Length | 185 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PALA54_RS17260 (PALA54_03410) | 3718598..3719149 | + | 552 | WP_034074903.1 | XRE family transcriptional regulator | - |
| PALA54_RS17265 (PALA54_03411) | 3719146..3719544 | - | 399 | WP_003088123.1 | NADH-quinone oxidoreductase subunit A | - |
| PALA54_RS17270 (PALA54_03412) | 3719557..3719880 | - | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
| PALA54_RS17275 (PALA54_03413) | 3720211..3720672 | + | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
| PALA54_RS17280 (PALA54_03414) | 3720677..3722872 | + | 2196 | WP_009314576.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
| PALA54_RS17285 (PALA54_03415) | 3723030..3723584 | + | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| PALA54_RS17290 (PALA54_03416) | 3723673..3724251 | + | 579 | WP_003118970.1 | HD domain-containing protein | Toxin |
| PALA54_RS17295 (PALA54_03417) | 3724361..3725548 | - | 1188 | WP_003110489.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
| PALA54_RS17300 (PALA54_03418) | 3725538..3727709 | - | 2172 | WP_023106617.1 | type I secretion system permease/ATPase | - |
| PALA54_RS17305 (PALA54_03419) | 3727699..3728976 | - | 1278 | WP_003088104.1 | TolC family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21899.72 Da Isoelectric Point: 5.3655
>T264825 WP_003118970.1 NZ_CP111032:3723673-3724251 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT264825 WP_003088112.1 NZ_CP111032:3723030-3723584 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|