264820

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 5156432..5157040 Replicon chromosome
Accession NZ_CP111030
Organism Pseudomonas aeruginosa strain PALA38

Toxin (Protein)


Gene name PfiT Uniprot ID A0A444LUU5
Locus tag PALA38_RS24160 Protein ID WP_019486378.1
Coordinates 5156432..5156779 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag PALA38_RS24165 Protein ID WP_003114155.1
Coordinates 5156789..5157040 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA38_RS24140 (PALA38_04770) 5152365..5152862 + 498 WP_116850177.1 heat resistance protein PsiE-GI -
PALA38_RS24145 (PALA38_04771) 5152840..5153805 + 966 WP_112778053.1 zinc metalloprotease HtpX -
PALA38_RS24150 (PALA38_04772) 5153830..5154981 + 1152 WP_004265443.1 trypsin-like peptidase domain-containing protein -
PALA38_RS24155 (PALA38_04773) 5155214..5156122 + 909 WP_003141085.1 LysR family transcriptional regulator -
PALA38_RS24160 (PALA38_04774) 5156432..5156779 - 348 WP_019486378.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA38_RS24165 5156789..5157040 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PALA38_RS24170 (PALA38_04775) 5157254..5158237 - 984 WP_003114154.1 tyrosine-type recombinase/integrase -
PALA38_RS24175 (PALA38_04776) 5158237..5159529 - 1293 WP_003115206.1 hypothetical protein -
PALA38_RS24180 (PALA38_04778) 5159759..5161042 - 1284 WP_023124144.1 zonular occludens toxin family protein -
PALA38_RS24185 (PALA38_04779) 5161046..5161402 - 357 WP_003114150.1 DUF2523 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5074563..5168287 93724


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12956.72 Da        Isoelectric Point: 4.4212

>T264820 WP_019486378.1 NZ_CP111030:c5156779-5156432 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT264820 WP_003114155.1 NZ_CP111030:c5157040-5156789 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A444LUU5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References