Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4690528..4691787 Replicon chromosome
Accession NZ_CP111030
Organism Pseudomonas aeruginosa strain PALA38

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag PALA38_RS21810 Protein ID WP_031686398.1
Coordinates 4690528..4691283 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PALA38_RS21815 Protein ID WP_003086329.1
Coordinates 4691419..4691787 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA38_RS21800 (PALA38_04310) 4685699..4688242 + 2544 WP_031686396.1 acyl-homoserine-lactone acylase QuiP -
PALA38_RS21805 (PALA38_04311) 4688397..4689758 - 1362 WP_073647918.1 DNA recombination protein RmuC -
PALA38_RS21810 (PALA38_04312) 4690528..4691283 - 756 WP_031686398.1 RES family NAD+ phosphorylase Toxin
PALA38_RS21815 (PALA38_04313) 4691419..4691787 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PALA38_RS21820 (PALA38_04314) 4691860..4693146 - 1287 WP_003086327.1 FAD-binding oxidoreductase -
PALA38_RS21825 (PALA38_04315) 4693202..4694791 - 1590 WP_003123191.1 aldehyde dehydrogenase family protein -
PALA38_RS21830 (PALA38_04316) 4694870..4695346 + 477 WP_031686399.1 elongation factor GreAB -
PALA38_RS21835 (PALA38_04317) 4695349..4695624 - 276 WP_023088486.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28296.42 Da        Isoelectric Point: 7.7297

>T264818 WP_031686398.1 NZ_CP111030:c4691283-4690528 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALRLETAMAESAYYRCVLWSGMAMPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT264818 WP_003086329.1 NZ_CP111030:c4691787-4691419 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References