264816

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 2657672..2658714 Replicon chromosome
Accession NZ_CP111030
Organism Pseudomonas aeruginosa strain PALA38

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag PALA38_RS12635 Protein ID WP_003109777.1
Coordinates 2658139..2658714 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag PALA38_RS12630 Protein ID WP_003050245.1
Coordinates 2657672..2658142 (+) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA38_RS12595 (PALA38_02494) 2653064..2654482 - 1419 WP_003109776.1 TIGR03752 family integrating conjugative element protein -
PALA38_RS12600 (PALA38_02495) 2654472..2655383 - 912 WP_003105643.1 TIGR03749 family integrating conjugative element protein -
PALA38_RS12605 (PALA38_02496) 2655380..2656072 - 693 WP_003105641.1 TIGR03746 family integrating conjugative element protein -
PALA38_RS12610 (PALA38_02497) 2656069..2656467 - 399 WP_003105639.1 TIGR03750 family conjugal transfer protein -
PALA38_RS12615 (PALA38_02498) 2656479..2656838 - 360 WP_003090173.1 TIGR03745 family integrating conjugative element membrane protein -
PALA38_RS12620 (PALA38_02499) 2656855..2657088 - 234 WP_003050225.1 TIGR03758 family integrating conjugative element protein -
PALA38_RS12625 (PALA38_02500) 2657085..2657468 - 384 WP_003105635.1 RAQPRD family integrative conjugative element protein -
PALA38_RS12630 (PALA38_02501) 2657672..2658142 + 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
PALA38_RS12635 (PALA38_02502) 2658139..2658714 + 576 WP_003109777.1 PIN domain-containing protein Toxin
PALA38_RS12640 (PALA38_02503) 2658732..2659646 + 915 WP_043084563.1 AAA family ATPase -
PALA38_RS12645 (PALA38_02504) 2659643..2660113 + 471 WP_003105626.1 type III CBASS phage resistance system CD-NTase-associated protein Cap8 -
PALA38_RS12650 (PALA38_02505) 2660110..2660610 + 501 WP_003090159.1 type III CBASS phage resistance system CD-NTase-associated protein Cap7 -
PALA38_RS12655 (PALA38_02506) 2660610..2661512 + 903 WP_003105624.1 CBASS oligonucleotide cyclase -
PALA38_RS12660 (PALA38_02507) 2661551..2662276 + 726 WP_003050273.1 CBASS effector endonuclease NucC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2607852..2703949 96097


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21644.79 Da        Isoelectric Point: 5.6172

>T264816 WP_003109777.1 NZ_CP111030:2658139-2658714 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPDDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIEVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT264816 WP_003050245.1 NZ_CP111030:2657672-2658142 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References