Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 150606..151111 Replicon chromosome
Accession NZ_CP111030
Organism Pseudomonas aeruginosa strain PALA38

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag PALA38_RS00700 Protein ID WP_003083773.1
Coordinates 150606..150887 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag PALA38_RS00705 Protein ID WP_003083775.1
Coordinates 150884..151111 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA38_RS00675 (PALA38_00129) 145857..147206 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
PALA38_RS00680 (PALA38_00130) 147255..147935 + 681 WP_043084877.1 FadR/GntR family transcriptional regulator -
PALA38_RS00685 (PALA38_00131) 148042..148776 + 735 WP_003083764.1 GntR family transcriptional regulator -
PALA38_RS00690 (PALA38_00132) 148956..149366 + 411 WP_003110659.1 aegerolysin family protein -
PALA38_RS00695 (PALA38_00133) 149398..150306 - 909 WP_003083769.1 LysR family transcriptional regulator -
PALA38_RS00700 (PALA38_00134) 150606..150887 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
PALA38_RS00705 (PALA38_00135) 150884..151111 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
PALA38_RS00710 (PALA38_00136) 151287..151907 - 621 WP_003101226.1 hypothetical protein -
PALA38_RS00715 (PALA38_00137) 152008..152508 + 501 WP_003162763.1 LEA type 2 family protein -
PALA38_RS00720 (PALA38_00138) 152581..152922 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
PALA38_RS00725 (PALA38_00139) 153004..154431 - 1428 WP_003083784.1 GABA permease -
PALA38_RS00730 (PALA38_00140) 154600..156093 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T264814 WP_003083773.1 NZ_CP111030:c150887-150606 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT264814 WP_003083775.1 NZ_CP111030:c151111-150884 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References