Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4108636..4109417 Replicon chromosome
Accession NZ_CP111029
Organism Salmonella sp. 2018103

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A752VN12
Locus tag OLG56_RS19895 Protein ID WP_000622305.1
Coordinates 4108636..4109127 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A3V4SIN7
Locus tag OLG56_RS19900 Protein ID WP_001110453.1
Coordinates 4109124..4109417 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLG56_RS19870 (4105590) 4105590..4106420 - 831 WP_079980926.1 fimbria/pilus periplasmic chaperone -
OLG56_RS19875 (4106622) 4106622..4106927 - 306 WP_000370555.1 PapB/FocB family fimbrial expression transcriptional regulator -
OLG56_RS19880 (4107459) 4107459..4107602 + 144 Protein_3884 transposase -
OLG56_RS19885 (4107619) 4107619..4107879 + 261 Protein_3885 Rpn family recombination-promoting nuclease/putative transposase -
OLG56_RS19890 (4108168) 4108168..4108401 - 234 Protein_3886 IS481 family transposase -
OLG56_RS19895 (4108636) 4108636..4109127 - 492 WP_000622305.1 GNAT family N-acetyltransferase Toxin
OLG56_RS19900 (4109124) 4109124..4109417 - 294 WP_001110453.1 DUF1778 domain-containing protein Antitoxin
OLG56_RS19905 (4109741) 4109741..4109963 + 223 Protein_3889 hypothetical protein -
OLG56_RS19910 (4110227) 4110227..4111102 + 876 WP_000921676.1 AraC family transcriptional regulator -
OLG56_RS19915 (4111099) 4111099..4111386 + 288 WP_001269916.1 transcriptional regulator RtsB -
OLG56_RS19920 (4111379) 4111379..4111561 - 183 WP_001527266.1 ATP-binding cassette domain-containing protein -
OLG56_RS19925 (4111581) 4111581..4111680 + 100 Protein_3893 hypothetical protein -
OLG56_RS19930 (4111790) 4111790..4111924 + 135 Protein_3894 hypothetical protein -
OLG56_RS19935 (4112219) 4112219..4113124 - 906 WP_001268209.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4098102..4111561 13459
- flank IS/Tn - - 4107625..4107888 263


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(2-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17606.43 Da        Isoelectric Point: 7.7297

>T264811 WP_000622305.1 NZ_CP111029:c4109127-4108636 [Salmonella sp. 2018103]
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10948.57 Da        Isoelectric Point: 9.8590

>AT264811 WP_001110453.1 NZ_CP111029:c4109417-4109124 [Salmonella sp. 2018103]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A752VN12

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIN7

References