Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3994965..3995481 Replicon chromosome
Accession NZ_CP111029
Organism Salmonella sp. 2018103

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag OLG56_RS19270 Protein ID WP_000220578.1
Coordinates 3994965..3995249 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A5I1C3W3
Locus tag OLG56_RS19275 Protein ID WP_000212722.1
Coordinates 3995239..3995481 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLG56_RS19255 (3990081) 3990081..3991733 + 1653 WP_000155039.1 alpha,alpha-phosphotrehalase -
OLG56_RS19260 (3992142) 3992142..3994280 + 2139 WP_000187815.1 anaerobic ribonucleoside-triphosphate reductase -
OLG56_RS19265 (3994497) 3994497..3994961 + 465 WP_001009178.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OLG56_RS19270 (3994965) 3994965..3995249 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OLG56_RS19275 (3995239) 3995239..3995481 - 243 WP_000212722.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OLG56_RS19280 (3995559) 3995559..3997472 - 1914 WP_139763604.1 BglG family transcription antiterminator -
OLG56_RS19285 (3997489) 3997489..3998229 - 741 WP_023229489.1 KDGP aldolase family protein -
OLG56_RS19290 (3998226) 3998226..3999344 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
OLG56_RS19295 (3999328) 3999328..4000461 - 1134 WP_001609909.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-64)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T264810 WP_000220578.1 NZ_CP111029:c3995249-3994965 [Salmonella sp. 2018103]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8988.37 Da        Isoelectric Point: 5.0651

>AT264810 WP_000212722.1 NZ_CP111029:c3995481-3995239 [Salmonella sp. 2018103]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDNEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5I1C3W3

References