Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3954337..3954887 Replicon chromosome
Accession NZ_CP111029
Organism Salmonella sp. 2018103

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag OLG56_RS19065 Protein ID WP_001199743.1
Coordinates 3954337..3954645 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V7ITQ8
Locus tag OLG56_RS19070 Protein ID WP_000016244.1
Coordinates 3954648..3954887 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLG56_RS19050 (3952365) 3952365..3953144 - 780 WP_001088805.1 HNH endonuclease -
OLG56_RS19055 (3953305) 3953305..3953619 + 315 WP_061377152.1 hypothetical protein -
OLG56_RS19060 (3953616) 3953616..3953903 - 288 WP_061377153.1 Arm DNA-binding domain-containing protein -
OLG56_RS19065 (3954337) 3954337..3954645 - 309 WP_001199743.1 CcdB family protein Toxin
OLG56_RS19070 (3954648) 3954648..3954887 - 240 WP_000016244.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
OLG56_RS19075 (3954996) 3954996..3955220 - 225 WP_031233173.1 ribbon-helix-helix protein, CopG family -
OLG56_RS19085 (3956005) 3956005..3957024 + 1020 WP_000152564.1 NAD(P)-dependent alcohol dehydrogenase -
OLG56_RS19090 (3957052) 3957052..3957582 - 531 WP_000896756.1 gluconokinase -
OLG56_RS19095 (3957799) 3957799..3958830 + 1032 WP_000453351.1 L-idonate 5-dehydrogenase -
OLG56_RS19100 (3958855) 3958855..3959619 + 765 WP_000998688.1 gluconate 5-dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T264809 WP_001199743.1 NZ_CP111029:c3954645-3954337 [Salmonella sp. 2018103]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8709.86 Da        Isoelectric Point: 6.4633

>AT264809 WP_000016244.1 NZ_CP111029:c3954887-3954648 [Salmonella sp. 2018103]
MSGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5T4R8

References