Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3304870..3305490 Replicon chromosome
Accession NZ_CP111029
Organism Salmonella sp. 2018103

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag OLG56_RS16110 Protein ID WP_001280991.1
Coordinates 3305272..3305490 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag OLG56_RS16105 Protein ID WP_000344807.1
Coordinates 3304870..3305244 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLG56_RS16095 (3300009) 3300009..3301202 + 1194 WP_079980911.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
OLG56_RS16100 (3301225) 3301225..3304374 + 3150 WP_039512904.1 efflux RND transporter permease AcrB -
OLG56_RS16105 (3304870) 3304870..3305244 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
OLG56_RS16110 (3305272) 3305272..3305490 + 219 WP_001280991.1 HHA domain-containing protein Toxin
OLG56_RS16115 (3305669) 3305669..3306220 + 552 WP_001278791.1 maltose O-acetyltransferase -
OLG56_RS16120 (3306338) 3306338..3306808 + 471 WP_000136183.1 YlaC family protein -
OLG56_RS16125 (3306864) 3306864..3307004 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
OLG56_RS16130 (3307010) 3307010..3307270 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
OLG56_RS16135 (3307495) 3307495..3309045 + 1551 WP_001642888.1 EAL domain-containing protein -
OLG56_RS16145 (3309276) 3309276..3309665 + 390 WP_000961285.1 MGMT family protein -
OLG56_RS16150 (3309698) 3309698..3310267 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T264808 WP_001280991.1 NZ_CP111029:3305272-3305490 [Salmonella sp. 2018103]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT264808 WP_000344807.1 NZ_CP111029:3304870-3305244 [Salmonella sp. 2018103]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References