264800

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 204334..205094 Replicon chromosome
Accession NZ_CP111029
Organism Salmonella sp. 2018103

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag OLG56_RS00960 Protein ID WP_000533909.1
Coordinates 204609..205094 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag OLG56_RS00955 Protein ID WP_000965886.1
Coordinates 204334..204621 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLG56_RS00930 (200333) 200333..200788 + 456 Protein_184 IS3 family transposase -
OLG56_RS00935 (200912) 200912..201700 + 789 Protein_185 IS3 family transposase -
OLG56_RS00940 (202013) 202013..202669 + 657 WP_235596638.1 hypothetical protein -
OLG56_RS00945 (202717) 202717..203004 + 288 WP_235596639.1 HNH endonuclease -
OLG56_RS00950 (203075) 203075..203701 - 627 WP_130559547.1 hypothetical protein -
OLG56_RS00955 (204334) 204334..204621 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
OLG56_RS00960 (204609) 204609..205094 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
OLG56_RS00965 (205466) 205466..206005 - 540 WP_000047140.1 copper-binding periplasmic metallochaperone CueP -
OLG56_RS00970 (206178) 206178..206390 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
OLG56_RS00975 (206678) 206678..206968 - 291 WP_000455790.1 HTH-type transcriptional regulator -
OLG56_RS00980 (207407) 207407..208117 + 711 WP_000190524.1 DUF3053 domain-containing protein -
OLG56_RS00985 (208167) 208167..209141 - 975 WP_000804678.1 glyoxylate/hydroxypyruvate reductase GhrB -
OLG56_RS00990 (209360) 209360..210022 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T264800 WP_000533909.1 NZ_CP111029:204609-205094 [Salmonella sp. 2018103]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT264800 WP_000965886.1 NZ_CP111029:204334-204621 [Salmonella sp. 2018103]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
AlphaFold DB A0A3V2JDX2

References